Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Fungi
Patent
1991-05-08
1993-06-08
Ellis, Joan
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Fungi
435 691, 435 693, 435 91, 4351723, 4352351, 4353201, 435256, 536 237, 530350, 935 10, 935 28, 935 37, 935 56, 935 65, 935 69, C12P 2102, C12P 1934, C12N 1500, C12N 700
Patent
active
052178986
ABSTRACT:
The present invention relates to transmission-blocking vaccines against malaria. Vaccines of the present invention contain a recombinant Pfs25 Plasmodium falciparum protein produced by yeast cells and to yeast cells producing the protein. Mice and monkeys inoculated with the yeast-expressed Pfs25 of the present invention have developed antibodies with transmission-blocking activity. The present invention also relates to methods of preventing or treating malarial infections using the vaccines of the present invention.
REFERENCES:
patent: 4546082 (1985-10-01), Kurjan et al.
Kaslow et al, Nature, vol. 333, pp. 74-76.
Barr et al, J. Biol. Chem, vol. 263, pp. 16471-16478, (1988).
Gibson, H. L., et al., "Expression in Yeast of Pfs25, A Sexual Stage Antigen of Plasmodium falciparum", The 38th Annual Meeting of the American Society of Tropical Medicine and Hygiene, Honolulu, Hawaii, Dec. 10-14, 1989.
Barr Philip J.
Kaslow David C.
Chiron Corporation
Ellis Joan
The United States of America as represented by the Secretary of
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