Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-07-25
1996-11-05
Sidberry, Hazel F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4242341, 4242361, 4242391, 4351723, 4353201, 536 231, 536 237, 935 1, 935 6, 935 33, 935 37, A61K 3908, C12N 1531, C12N 1537, C12P 2102
Patent
active
055716946
ABSTRACT:
Expression of tetanus toxin fragment C is accomplished employing a DNA coding sequence having a (G+C)-content that has been increased in the region from nucleotide 410 to the 3' end of the coding sequence relative to the wild-type DNA sequence. This allows the production of complete mRNA transcripts. Typically the (G+C)-content is increased in the following regions: (i) nucleotides 510-710, (ii) nucleotides 650-850, (iii) nucleotides 800-1100, (iv) nucleotides 900-1200 and (v) nucleotides 1100-1356. These regions in wild-type DNA encompass terminator sequences.
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Clare Jeffrey J.
Fairweather Neil F.
Makoff Andrew J.
Romanos Michael A.
Evans Medical Limited
Krsek-Staples Julie
Sidberry Hazel F.
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