Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-12-17
1997-01-07
Smith, Lynette F.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
4241841, 4241881, 4242061, 4242081, 4242091, 4242011, 435 5, C07K 100, C12Q 170, A61K 3900, A61K 39145
Patent
active
055918239
ABSTRACT:
Chimeric DNA fragments are provided which include a nucleotide sequence substantially the same as that which codes for the HA surface protein of an influenza A virus having five immunodominant antigenic sites, wherein a nucleotide sequence substantially the same as that which codes for a foreign epitope is inserted into the nucleotide sequence of an antigenic site. Corresponding chimeric peptides, expression vectors, and transformed hosts are provided as well. These peptides are useful in providing vaccines against the respective antigens and in test kits to detect the exposure to such antigens. Additionally, these peptides or their corresponding antibodies are useful in methods of treatment and prevention of the manifestations of exposure to these antigens, including immunotherapy.
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Hung Paul P.
Kalyan Narender K.
Lee Shaw-guang L.
American Home Products Corporation
Jackson Richard K.
Smith Lynette F.
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