Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1995-06-06
1997-11-04
Ketter, James
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424 932, 4352523, 4352528, A61K 3900
Patent
active
056837003
ABSTRACT:
The invention concerns a method of prophylactically treating a host against infection by a microorganism, which method comprises administering to the host an attenuated Salmonella bacterium which contains a nirB promoter operably linked to a DNA sequence encoding a heterologous protein. The heterologous protein is expressed in the host and induces in the host an immune response against the microorganism.
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Charles Ian George
Chatfield Steven Neville
Fairweather Neil Fraser
Glaxo Wellcome Inc.
Ketter James
Yucel Irem
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