Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1989-12-28
1992-08-25
Ellis, Joan
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 91, 4351723, 4352351, 4353201.240.2, 4352523, 43525233, 435255, 435256, 536 27, 530350, 935 9, 935 29, 935 31, 935 32, 935 34, 935 41, 935 37, 935 55, 935 69, 935 70, 935 72, 935 73, C12P 2102, C12P 1934, C12N 1500, C12N 700, C12N 500, C12N 121, C12N 116, C12N 11815/70, C12N 1585, C07K 300, C07H 1512
Patent
active
051418568
ABSTRACT:
A ciliary neurotrophic factor (CNTF), particularly sciatic nerve CNTF (SN-CNTF) is claimed. The SN-CNTF described herein is a single protein species and has a specific activity that increased to greater than 25,000-fold from crude extract.
Amino acid data for this SN-CNTF is also provided. In addition, methods for using this data for providing SN-CNTF probes and for screening cDNA and genomic libraries are also provided. Recombinant-DNA methods for the production of SN-CNTF are described.
Nucleic acid sequences encoding rabbit and human CNTF are provided. A recombinant expression system is provided for producing biologically active CNTF.
Collins Franklin D.
Ko Christine
Lin Leu-Fen
Mismer Drzislav
Ellis Joan
Synergen, Inc.
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