Expression of protein C

Details Expression of protein C Expression of protein C

1986-10-29

1990-09-25

Mays, Thomas D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435226, 43524025, 435320, 435849, 536 27, 935 14, 935 29, 935 32, 935 48, C12N 1500, C12N 964, C12N 502, C07H 1512

Patent

active

049593188

ABSTRACT:
Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C and recombinant transfer vectors comprising these sequences are disclosed.
Methods are disclosed for producing a protein which has substantially the same biological activity as human protein C. The protein, which may be in the form of activated protein C, is produced by mammalian host cells transfected with a plasmid capable of integration in mammalian host cell DNA. The plasmid includes a promoter followed downstream by a nucleotide sequence which encodes a protein having substantially the same structure and/or activity as human protein C, the nucleotide sequence being followed downstream by a polyadenylation signal.

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