Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-11-02
1997-01-14
Fox, David T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
4353201, 435 691, 435 698, 435196, 4352523, 4352404, 4351723, 514 44, 426 53, 426 54, 426635, 424 9321, 800205, 800250, 800255, 536 241, 536 2374, A61K 3846, C12N 1583, A01H 500, A23K 1165
Patent
active
055939635
ABSTRACT:
The present invention provides for the expression of phytase in transgenic plants or plant organs and methods for the production of such plants. DNA expression constructs are provided for the transformation of plants with a gene encoding phytase under the control of regulatory sequences which are capable of directing the expression of phytase. These regulatory sequences include sequences capable of directing transcription in plants, either constitutively, or stage and/or tissue specific, depending on the use of the plant or parts thereof. The transgenic plants and plant organs provided by the present invention may be applied to a variety of industrial processes either directly, e.g. in animal feeds or alternatively, the expressed phytase may be extracted and if desired, purified before application.
REFERENCES:
patent: 3297548 (1967-01-01), Ware et al.
patent: 4116770 (1978-09-01), Goering et al.
patent: 4859486 (1989-08-01), Douglass
B. J. C. Cornelissen et al. Nature, vol. 321 (29 May '86) pp. 531-532.
T. Ohtani et al. Plant Mol. Biol., vol. 16 ('91) pp. 117-128.
B. Larkins et al. J. Cell Biochem, vol. Suppl. O (9 Part C) p. 264.
J. Sambrook et al., Molecular Cloning--A Lab. Manual, CSHL Press, 1989, pp. 11.2-11.19, 11.45-11.49, 11.52-11.61.
K. Ehrlich et al. Biochemical & Biophysical Research Communications, vol. 195 #1 ('93) pp. 53-57.
R. Freedman Cell, vol. 57, (Jun. 30, 1989) pp. 1069-1072.
E. Mullaney Mycologia, vol. 85(1) pp. 71-73 (1993).
Altenbach et al., "Enhancement of the methionine content of seed proteins by the expression of a chimeric gene encoding a methionine-rich protein in transgenic plants" Plant Mol. Biol. (1989) 13(5):513-522.
Barker et al., "Cellular localization of soybean storage protein messenger RNA in transformed tobacco seeds" Proc. Natl. Acad. Sci. USA (1988) 85(2):458-462.
Bustos et al., "Regulation of beta glucuronidase expression in transgenic tobacco plants by an adenosine thymidine-rich cis-acting sequence found upstream of a french bean beta phaseolin gene" Plant Cell (1989) 1(9):839-854.
Casey et al., "The structure of plant storage protein genes" Plant Mol. Biol. Reporter (1987) 5(2):261-281.
Christen et al., "Cloning of the phytase gene from germinating soybeans" J. Cell Biochem. (1988) Supplement 12, Part C, p. 190, (abstract No. L402).
Ellis et al., "Tissue-specific expression of a pea legumin gene in seeds of Nicotiana plumbaginifolia" Plant Mol. Biol. (1988) 10(3):203-214.
Gibson et al., "Phytase expression during seed germination" J. Cell Biochem. (1988) Supplemental 12, Part C, p. 192 (abstract No. L407).
Higgins et al., "The sequence of a pea vicilin gene and its expression in transgenic tobacco plants" Plant Mol. Biol. (1988) 11(5):683-696.
Hoffman et al., "Synthesis and protein body deposition of maize 15-kD zein in transgenic tobacco seeds" EMBO J. (1987) 6(11):3213-3222.
Iturriaga et al., "Endoplasmic reticulum targeting and glycosylation of hybrid proteins in transgenic tobacco" Plant Cell (1989) 1:381-390.
Krebbers et al., "Production of peptides in plant seeds" Trends in Biotechnol. (1990) 8(1):1-3.
Shotwell et al., In: The Biochemistry of Plants, vol. 15, Stumpf, P. K. & Conn, E. E., eds. (Academic Press, San Diego, 1989), chap. 7, pp. 297-345.
Sijmons et al., "Production of correctly processed human serum albumin in transgenic plants" Biotechnology (1990) 8(3):217-221.
Vandekerckhove et al., "Enkephalins produced in transgenic plants using modified 2S seed storage proteins" Biotechnology (1989) 7:929-932.
Voelker et al., "In-vitro mutated phytohemagglutinin genes expressed in tobacco seeds: role of glycans in protein targeting and stability" Plant Cell (1989) 1(1):95-104.
Derwent Publication "Alerting Abstracts Bulletin", Abstract No. 90-210631/28, which abstracts DDR application 23.09.88-DD-320082 (31 Jan. 1990).
Han et al., "Phytate hydrolysis in soybean and cottonseed meals by Aspergillus ficuum phytase" J. Agric. Food Chem. (1988) 36(2):259-262.
Han, Y. W., "Removal of phytic acid form soybean and cottonseed meals" J. Agric. Food Chem. (1988) 36(6):1181-1183.
Patent Abstracts of Japan vol. 9, No. 17, (C-262) [1740] Jan. 24, 1985.
Jordano et al., "A sunflower helianthinin gene upstream sequence ensemble contains an enhancer and sites of nuclear protein interaction" Plant Cell (1989) 1(9):855-866.
Hesselman et al., "The effect of .beta.-glucanase on the utilizaton of starch and nitrogen by broiler chickens fed on barley of low-or-high-viscosity" Chem. Abstracts. (1986) 105:574 (abstract No. 132749x).
Broz et al., "Effects of beta-glucanase on the feeding value of broiler diets based on barley or oats" Chem. Abstracts (1986) 105:569 (abstract No. 23478n).
Gopaldas et al., "Studies on a wheat-based amylase-rich food" Food Science Technol. Abstracts (1989) 21(8):123 (abstract 8 M 19).
Colot et al., "Localization of sequences in wheat endosperm protein genes which confer tissue-specific expression in tobacco" EMBO J. (1987) 6(12):3559-3564.
Ullah et al., "Extracellular phytase (E.C. 3.1.3.8) from Aspergillus ficuum NRRL 3135: purification and characterization" Prep. Biochem. (1987) 17(1):63-91.
Jahne et al., "Regeneration of fertile plants from protoplasts derived from embryogenic cell suspensions of barley" (Hordeum vulgare L.) Plant Cell Reports (1991) 10:1-6.
Gibson et al., "Purification and characterizaton of phytase from cotyledons of germinating soybean seeds" Arch. Biochem. Biophys. (1988) 260(2):503-513.
Abersold et al., "Internal amino acid sequence analysis of proteins separated by one- or two-dimensional gel electrophoresis after in situ protease digestion on nitrocellulase" Proc. Natl. Acad. Sci. USA (1987) 84:6970-6974.
Jaye et al., "Isolation of human anti-haemophilic factor IX cDNA clone using a unique 52-Base synthetic oligonucleotide probe derived from the amino acid sequence of bovine factor IX" Nucl. Acids Res. (1983) 11(8):2325-2335.
Dorel et al., "Transport of proteins to the plant vacuole is not by bulk flow through the secretory system, and requires positive sorting information" J. Cell Biol. (1989) 108:327-337.
Della-Chioppa et al., "Protein trafficking in plant cells" Plant Physiol. (1987) 84:965-968.
Hoffman et al., "A modified storage protein is synthesized, processed, and degraded in the seeds of transgenic plants" Plant Mol. Biol. (1988) 11:717-729.
Biosys Computer Database Abstract of Yang et al., "Purification and characterization of phytase from rat intestinal mucosa" Biochem. Biophys. Acta (1991) 1075(1):75-82. (Biosys No. 92122246).
Freedman et al., "Protein disulfide isomerase: multiple roles in the modification of nascent secretory proteins" Cell (1989) 57:1069-1072.
Perlman et al., "A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides" J. Mol. Biol. (1983) 167:391-409.
von Heijne, G., "How signal sequences maintain cleavage specificity" J. Mol. Biol. (1984) 173:243-251.
Biosys Computer Database Abstract of Goel et al., "Multiple forms of phytase EC-3.1.3.8 in germinating cotyledons of Cucurbita maxima" Phytochemistry (1979) 18(12):1939-1942. (Biosys No. 70046645).
Biosys Computer Database Abstract of Pospisil et al., "The influence of humic acids on phytase activity isolated from wheat seeds" Biol. Plant (1975) 17(6):468-474. (Biosys No. 61051479).
Biosys Computer Database Abstract of Yoshida et al., "Phytase EC-3.1.3.8 activity associated with isolated aleurone particles of rice grains" Agric. Biol. Chem. (1975) 39(1):289-290. (Biosys No. 60051490).
Biosys Computer Database Abstract of Chan et al., "Distribution and properties of calcium atpase EC-3.6.1.3 phytase EC-3.1.3.8 and alkaline phosphatase EC-3.1.3.1 in isolated enterocytes from normal and vitamin D deficient rats" Gut (1983) 24(10):886-892. (Biosys No. 77085639).
Chrispeels, M. J., "Sorting of proteins in the secretory system" Ann. Rev. Plant Physiol. Plant Mol. Biol. (1991) 42:1-24.
John et al., "Reduction in the dietary bulk of soya-fortified bulgur wheat gruels with wheat-based amylase-rich food" Food Science Technol. Abstracts (1989) 21(12):124 (abstract No. 12 M 11).
Hoekema Andreas
Pen Jan
Rietveld Krijn
Sijmons Peter C.
Van Ooijen Albert J. J.
Fox David T.
Gist-Brocades B.V.
Mogen International
Rories Charles C. P.
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