Expression of neurogenic bHLH genes in primitive neuroectodermal

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 34, 435 691, 536 231, C12Q 168, C12Q 104, C12P 2102, C07H 2104

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057957231

ABSTRACT:
Provided are methods of classifying and prognosticating human neuroectodermal tumors by analyzing a sample of the tumor to determine whether various bHLH proteins are detectably expressed in the sample. In the methods disclosed herein, expression of the bHLH genes is assessed by measuring transcripts or proteins expressed from the genes.

REFERENCES:
patent: 5302519 (1994-04-01), Blackwood et al.
patent: 5322801 (1994-06-01), Kingston et al.
patent: 5352595 (1994-10-01), Tapscott et al.
patent: 5695995 (1997-12-01), Weintraub et al.
Maniatis et al., "Molecular cloning: A Laboratory Manual," Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1982, p. 227.
Wilson, P.A. et al., "Induction of epidermis and inhibition of neural fate by Bmp-4," Nature, 376:331-333 (1995).
Lee, J.E. et al., "Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein," Science, 268:836-844 (1995).
Shimizu, C. et al., "MATH-2, a mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal, is specifically expressed in the nervous system," Eur. J. Biochem., 229:239-248 (1995).
Naya, F.J. et al., "Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor," Genes and Development, 9:1009-1019 (1995).
Singson, A. et al., "Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling," Genes & Development, 8:2058-2071 (1994).
Turner, D.L. et al., "Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate," Genes & Development, 8:1434-1447 (1994).
Rupp, R.A.W. et al., "Xenopus embryos regulate the nuclear localization of XMyoD," Genes & Development, 8:1311-1323 (1994).
Buffinger, N. et al., "Myogenic specification in somites: induction by axial structures," Development, 120:1443-1452 (1994).
Kramatschek, B. et al., "Neuroectodermal transcription of the Drosophila neurogenic genes E(spl) and HLH-m5 is regulated by proneural genes," Development, 120:815-826 (1994).
Burcin, M. et al., "Factors influencing nuclear receptors in transcriptional repression," Cancer Biology, 5:337-346 (1994).
Rudnicki, M.A. et al., "MyoD or Myf-5 Is Required for the Formation of Skeletal Muscle," Cell, 75:1351-1359 (1993).
Guillemot, F. et al., "Mammalian achaete-scute Homolog 1 Is Required for the Early Development of Olfactory and Autonomic Neurons," Cell, 75:463-476 (1993).
Lamb, T.M. et al., "Neural Induction by the Secreted Polypeptide Noggin," Science, 262:713-718 (1993).
Hasty, P. et al., "Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene," Nature, 364:501-506 (1993).
Nabeshima, Y. et al., "Myogenin gene disruption results in perinatal lethality because of severe muscle defect," Nature, 364:532-535 (1993).
Guillemot, F. et al., "Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system," Mechanisms of Development, 42:171-185 (1993).
Rong, P.M et al., "The neural tube
otochord complex is necessary for vertebral but not limb and body wall striated muscle differentiation," Development, 115:657-672 (1992).
Lo, L.C. et al., "Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells," Genes & Development, 5:1524-1537 (1991).
Blackwood, E.M. et al., "Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc," Science, 251:1211-1217 (1991).
Johnson, J.E. et al., "Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors," Nature, 346:858-861 (1990).
Gobel et al., "NSCL-2: A Basic Domain Helix-Loop-Helix Gene Expressed in Early Neurogenesis," Cell Growth and Diff., 3:143-148 (1992).
Ball, D.W. et al., "Identification of a Human Achaete-Schute Homolog Highly Expressed in Neuroendocrine Tumors," Proc. Natl. Acad. Sci. USA, 90:5648-5652 (1993).
Biegel, J.A. et al., "Isochromosome 17q Demonstrated by Interphase Fluorescence In Situ Hybridization in Primitive Neuroectodermal Tumors of the Central Nervous System," Genes, Chromo. & Cancer, 14:85-96 (1995).
Trojanowski, J.Q. et al., "Medulloblastomas and Related Privitive Neuroectodermal Brain Tumors of Childhood Recapitulate Molecular Milestones in the Maturation of Neuroblasts," Mol. & Chem. Neuro., 17:121-135 (1992).
Schutz, B.R. et al., "Mapping of Chromosomal Gains and Losses in Primitive Neuroectodermal Tumors by Comparative Genomic Hybridization," Genes, Chromo. & Cancer, 16:196-203 (1996).
Kozmik, Z. et al., "Deregulated Expression of PAX5 in Medulloblastoma," Proc. Natl. Acad. Sci. USA, 92:5709-5713 (1995).
Clark, J. et al., "Expression of Members of the MYF Gene Family in Human Rhabdomyosarcomas," Br. J. Cancer, 64:1039-1042 (1991).

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