Chemistry: molecular biology and microbiology – Vector – per se
Patent
1992-01-09
1994-12-27
Draper, Garnette D.
Chemistry: molecular biology and microbiology
Vector, per se
4352523, 4352401, 435 6951, 435 9141, 536 2352, 424 854, 935 23, 935 56, A61K 3821, C07K 14555, C12N 1520
Patent
active
053765672
ABSTRACT:
DNA constructs are prepared which operably link human interferon genes, selective, eukaryotic marker genes, and promoter and expression control sequences for the expression of human interferon in Chinese hamster ovary (CHO) cells or progeny thereof. The human recombinant interferon so produced contains glycans which are a subset of the population of glycans which are contained in the native counterpart, and may be used in therapeutic formulations. The CHO cells yield high levels of human interferon with no detectable amounts of host, IFN, either constitutive or inductive.
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Innis Michael A.
McCormick Francis P.
Ringold Gordon M.
Berlex Laboratories Inc.
Board of Trustees of the Leland Stanford Jr. Univ.
Cermak Shelly Guest
Draper Garnette D.
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