Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1985-07-31
1990-10-30
Martinell, James
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 701, 435 703, 435 705, 4351721, 4351723, 4352402, 435320, 435811, 536 27, 935 11, 935 34, 935 70, C12P 2800, C12N 1500, C12N 500, C07H 2104
Patent
active
049668439
ABSTRACT:
DNA constructs are prepared which operably link human interferon genes, selective, eukaryotic marker genes, and promoter and expression control sequences for the expression of human interferon in Chinese hamster ovary (CHO) cells or progeny thereof. The human recombinant interferon so produced contains glycans which are a subset of the population of glycans which are contained in the native counterpart, and may be used in therapeutic formulations. The CHO cells yield high levels of human interferon with no detectable amounts of host IFN, either constitutive or inductive.
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Innis Michael A.
McCormick Francis P.
Ringold Gordon M.
Cetus Corporation
Halluin Albert P.
Hasak Janet E.
Martinell James
McGarrigle Philip L.
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