Expression of human proapolipoprotein A-I

Details Expression of human proapolipoprotein A-I Expression of human proapolipoprotein A-I

1988-05-26

1991-10-22

Teskin, Robin L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 4353201, 435255, 435256, 4352523, 4352402, 536 27, 935 11, 935 13, 935 44, 935 45, 935 39, C12P 2106, C12N 1500, C07H 1512

Patent

active

050595288

ABSTRACT:
The present invention provides recombinant DNA sequences comprising a sequence which codes for human proapolipoprotein A-I wherein part of the natural coding sequence has been replaced by a DNA fragment coding for the same amino acids but consisting of a different nucleotide sequence such as to reduce or prevent formation of hairpins, cloning and expression vectors containing these DNA sequences, cell cultures or microorganisms transformed with these expression vectors and processes using the same for the production of proapolipoprotein A-I.

REFERENCES:
Wood et al. Nucl. Acids Res., vol. 12 (9) pp. 3937-3950, 1984, "The influence of messenger RNA secondary structure on expression of an immunoglobulin heavy chain in Escherichia coli".
Cabezon et al., Proc. Natl. Acad. Sci., vol. 81(21), pp. 6594-6598, 1984, "Expression of human .alpha. 1-antitrypsin cDNA in the yeast Saccharomyces cerevisiae".
Lorenzetti et al., FEBS Lett., vol. 194(2), pp. 343-346, 1986, "Expression of the human apolipoprotein AI gene fused to the E. coli gene for .beta.-galactosidase".
Mallory et al., J. Biol. Chem. vol. 262(9), pp. 4241-4247, 1987, "Expression and Characterization of human apolipoprotein A-I in Chinese hamster ovary cells ".
Queen et al., J. Mol. Appl. Genet., vol. 2, 1983, pp. 1-10.
Ghrayeb et al., MBO J., vol. 3, 1984, pp. 2437-2442.
Matsuura et al., J. Gen. Virol., vol. 67, 1986, pp. 1515-1529.

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