Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1988-05-26
1991-10-22
Teskin, Robin L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 4353201, 435255, 435256, 4352523, 4352402, 536 27, 935 11, 935 13, 935 44, 935 45, 935 39, C12P 2106, C12N 1500, C07H 1512
Patent
active
050595288
ABSTRACT:
The present invention provides recombinant DNA sequences comprising a sequence which codes for human proapolipoprotein A-I wherein part of the natural coding sequence has been replaced by a DNA fragment coding for the same amino acids but consisting of a different nucleotide sequence such as to reduce or prevent formation of hairpins, cloning and expression vectors containing these DNA sequences, cell cultures or microorganisms transformed with these expression vectors and processes using the same for the production of proapolipoprotein A-I.
REFERENCES:
Wood et al. Nucl. Acids Res., vol. 12 (9) pp. 3937-3950, 1984, "The influence of messenger RNA secondary structure on expression of an immunoglobulin heavy chain in Escherichia coli".
Cabezon et al., Proc. Natl. Acad. Sci., vol. 81(21), pp. 6594-6598, 1984, "Expression of human .alpha. 1-antitrypsin cDNA in the yeast Saccharomyces cerevisiae".
Lorenzetti et al., FEBS Lett., vol. 194(2), pp. 343-346, 1986, "Expression of the human apolipoprotein AI gene fused to the E. coli gene for .beta.-galactosidase".
Mallory et al., J. Biol. Chem. vol. 262(9), pp. 4241-4247, 1987, "Expression and Characterization of human apolipoprotein A-I in Chinese hamster ovary cells ".
Queen et al., J. Mol. Appl. Genet., vol. 2, 1983, pp. 1-10.
Ghrayeb et al., MBO J., vol. 3, 1984, pp. 2437-2442.
Matsuura et al., J. Gen. Virol., vol. 67, 1986, pp. 1515-1529.
Bollen Alex
Gobert Jean
Wulfert Ernst
Teskin Robin L.
UCB S.A.
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