Expression of HIV1 and HIV2 polypeptides and their use

Details Expression of HIV1 and HIV2 polypeptides and their use Expression of HIV1 and HIV2 polypeptides and their use

1991-01-25

1994-05-10

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 5, 935 12, 536 2372, 424 89, C07K 300, C12Q 170, C07H 1512

Patent

active

053108760

ABSTRACT:
A fusion protein with at least one antigenic and/or immunogenic determinant from the env, gag and/or pol region of HIV1 and/or HIV2 which contains the tetrapeptide sequence NH.sub.2 -Met-Tyr-Tyr-Leu as the N-terminal component as well as a process for its production and use.

REFERENCES:
Guyader, et al., 1987, "Genome organization and transactivation of . . . " Nature 326: 662-669.
Shoeman, et al, 1987, "Comparison of recombinant human immunodeficiency . . . " Analytical Biochem. 161:370-379.
Cabradilla, et al., 1986, "Serodiagnosis of antibodies to the human AIDS . . . " Bioltechnology 4:128-133.
Structural Requirements for Bacterial Expression of Stable, Enzymatically Active Fusion Proteins Containing the Human Immunodeficiency Virus Reverse Transcriptase, DNA, vol. 7, No. 6, 1988, pp. 407-416, by Naoko Tanese et al.
European Search Report, Mar. 9, 1993, EP 91 10 1224.

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