Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2008-03-25
2008-03-25
Chen, Stacy B. (Department: 1648)
Chemistry: molecular biology and microbiology
Vector, per se
C424S208100
Reexamination Certificate
active
07348177
ABSTRACT:
The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
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Hartog Karin
Lian Ying
Chen Stacy B.
Lee Helen
Novartis Vaccines and Diagnostics Inc.
Pasternak Dahna S.
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