Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2006-02-28
2006-02-28
Falk, Anne-Marie (Department: 1635)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S320100, C435S352000, C435S463000
Reexamination Certificate
active
07005299
ABSTRACT:
A gene trap vector comprises a DNA construct containing an expression unit of an internal ribosome binding site (IRES) coupled to a heterologous gene sequence; this expression unit is used in gene trap protocols to obtain expression of the heterologous gene in the host.
REFERENCES:
patent: 6150169 (2000-11-01), Smith et al.
patent: 6248934 (2001-06-01), Tessler-Lavigne et al.
patent: WO 90/11354 (1990-10-01), None
patent: WO 91/06667 (1991-05-01), None
patent: WO 92/20808 (1992-11-01), None
patent: WO 93/07266 (1993-04-01), None
patent: WO 93/09222 (1993-05-01), None
Skarnes, W.C. 1990 Biotechnology, vol. 8, pp. 827-831.
Tsukiyama-Kohara, K. et al 1992 J. of Virology, vol. 66 (3), pp. 1476-1483.
Ghattas, I.R. 1991 Mol. and Cell. Biol. vol. 11 (12), pp. 5848-5859.
Sambrook et al 1989. Molecular Cloning, A Laboratory Manual. Chapter 18, p. 18.81. Pub. Cold Spring Harbor Lab. Press.
Mullins et.al.; Perspectives Series: Molecular Medicine in Gentically Engineered Animals, 1996, J. Clin. Invest., vol. 98: S37-S40.
Houdebine; Production of pharmaceutical proteins from transgenic animals, 1994, Journal of Biotechnology 34: 269-287.
Wall; Transgenic Livestock: Progress and Prospects for the Future, 1996, Theriogenology 45: 57-68.
Holscneider, D.P. et al. Genotype of phenotype: challenges and opportunities. International Journal of Developmental Neuroscience, 2000, vol. 18, pp. 615-618.
Ryan, M.J. et al. Use of transgenic and knockout strategies in mice. Seminars in Nephrology, 2002, vol. 22, pp. 154-160.
Ali, S. et al., “Characterization of the Gene Encoding Ovine Beta-Lactoglobulin: Similarity to the Genes for Retinol Binding Protein and Other Secretory Proteins,” J. Mol. Biol. 199:415-426 (1988).
Archibald, A.L. et al., “High-Level expression of biologically active human ∝1-antitrypsin in the milk of transgenic mice,” Proc. Natl. Acad. Sci. USA 87:5178-5182 (1990).
Brinster, R.L. et al., “Introns increase transcriptional efficiency in transgenic mice,” Proc. Natl. Acad. Sci. USA 85:836-840 (1988).
Clark, A.J. et al., “Expression of Human Anti-emophilic Factor IX in the Milk of Transgenic Sheep,” Bio/technology 7:487-492 (1989).
Friedrich, G. et al., “Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in ice,” Genes Devel. 5:1513-1523 (1991).
Ghattas, I.R. et al., “The Encephalomyocarditis Virus Internal Ribosome Entry Site Allows Efficient Coexpression of Two Genes frm a Recombinant Provirus in Cultured Cells and in Embryos,” Mol. Cell. Biol. 11(12):5848-5859 (1991).
Gossler, A. et al., “Mouse Embryonic Stem Cells and Reporter Constructs to Detect Developmentally Regulated Genes,” Science 244:463-465 (1989).
Harris, S. et al., “Complete nucleotide sequence of the genomic ovine β-lactoglobul in gene”, Nucl. Acids Res. 16(21): 10379-10380 (1988).
Heard, J.-M et al., “Determinants of Rat Albumin Promoter Tissue Specificity Analyzed by an Improved Transient Expression System,” Mol. Cell. Biol. 7(7):2425-2434 (1987).
Lathe, R. et al., “Plasmid and bacteriophage vectors for excision of intact inserts,” Gene 57:193-201 (1987).
Nicholos, J. et al., “Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity,” Development 110:1341-1348 (1990).
Okamoto, K. et al., “A Novel Octamer Binding Transcription Factor Is Differential Expressed in Mouse Embryonic Cells,” Cell 60:461-472 (1990).
Pelletier, J. et al., “Internal initiation of translation of eukaryotic MRNA directed by a sequence derived from poliovirus RNA,” Nature 334:320-325 (1988).
Pilipenko, E. V. et al., “Prokaryotic-like Cis Elements in the Cap-Independent Internal Initiation of Translation on Picornavirus RNA”, Cell 68: 119-131 (Jan. 1992).
Scholer, H.R. et al., “Octamer binding proteins confer transcriptional activity in early mouse embryogenesis,” EMBO J. 8(9):2551-2557 (1989).
Scholer, H.R. et al., “Oct-4: a germline-specific transcription factor mapping to the mouse t-complex,” EMBO J. 9(7):2185-2195 (1990).
Scholer, H.R. et al., “Octomania: The POU factors in murine development,” Trends Genet. 7(10):323-329 (1991).
Simons, J.P. et al., “Alteration of the quality of milk by expression of sheep β-lactoglobulin in transgenic mice,” Nature 328:530-532 (1987).
Skarnes, W.C., et al., “A gene trap approach in mouse embryonic stel cells: the lacZ reporter is activated by splicing, reflects endogenous gene expression, and is mutaenic in mice,” Genes Develop. 6:903-918 (Jun. 1992).
Smith, A.G. et al., “Targeted Mutagenesis of the Stem Cell Specific Transcription Factor Oct-4”, J. Cell. Biochem. Suppl. 18B:189 (Feb. 1994).
Tomasetto, C. et al., “Breast Cancer Protein PS2 Synthesis in Mammary Gland of Transgenic Mice and Secretion into Milk,” Mol. Endocrinol. 3:1579-1584 (1989).
Ure, J.M. et al., “A rapid and efficient method for freezing and recovering clones of embryonic stem cells,” Trends Genet. 8(1):6 (Jan. 1992).
Whitelaw, C.B.A. et al., “Targeting expression to the mammary gland: intronic sequences can enhance the efficiency of gene expression in transgenic mice,” Transgenic Res. 1:3-13 (1991).
Wood, C.R. et al., “An internal ribosome binding site can be used to select for homologous recombinants at an immunoglobulin heavy-chain locus,” Proc. Natl. Acad. Sci, USA 88:8006-1810.
Glenn Friedrich, et al.: Promotor Traps in Embryonic Stem Cells; A Genetic Screen to Identify and Mutate Developmental Genes in Mice; Jul. 1, 1999; pp. 1513-1523; Genes & Development.
Achim Gossler, et al.; Mouse Embryonic Stem Cells and Reporter Constructs to Detect Developmentally Regulated Genes; Apr. 28, 1989; pp. 463-465; Reports.
Alexandra L. Joyner; Gene Targeting and Gene Trap Screens Using Embryonic Stem Cells; New Approaches to Mammalian Development; Dec. 1991; pp. 649-656; BioEssays.
William C. Skarnes, et al.; A Gene Trap Approach in Mouse Embryonic Stem Cells; The LacZ Reporter is Activated by Splicing, Reflects Endogenous Gene Expression, and is Mutagenic in Mice; Mar. 26, 1992; pp903-918; Genes & Deveopment.
Elizabeth Robertson, et al.; Germ-Line Transmission of Genes Introduced into Cultured Pluripotential Cells by Retroviral Vector; Oct. 2, 1986; pp. 445-448; Letterstonature.
Ingrid R. Ghattas, et al.; The Encephalomyocarditis Virus Internal Ribosome Entry Site Allows Efficient Coexpression of Two Genes from a Recombinant Provirus in Cultured Cells and in Embryos; Molecular and Cellular Biology, Dec. 1991; pp. 5848-5859.
Kyoko Tsukiyama-Kohara, et al.; Internal Ribosome Entry Site Within Hepatitis C Virus RNA; Journal of Virology, Mar. 1991, pp. 1476-1483.
William C. Skarnes; Entrapment Vectors; A New Tool for Mammalian Genetics; Bio/Technology; vol. 8; Sep. 1990; pp. 827-831.
Linda J. Mullins, et al.; Perspective Series: Molecular Medicine in Genetically Engineered Animals; Transgenesis in Nonmurine Species; pp. S37-S40.
Louis-Marie Houdebine; Production of Pharmaceutical Proteins from Transgenic Animals; Journal of Biotechnology; (1994); p269-287.
R.J. Wall; Transgenic Livestock: Progress and Prospects for the Future; Gene Evaluation and Mapping Laboratory, Agricultural Research Service, USDA; (1996) pp. 57-68.
D.G. Kim, et al.; “Construction of a Bifunctional mRNA in the Mouse by Using the Internal Ribosomal Entry Site of the Encephalomyocarditis Virus”; Molecular and Cellular Biology, Aug. 1992, p. 3636-3643; vol. 12, No. 8.
William C. Skarnes, B. Anna Auerbach, and Alexandra L. Joyner; A gene trap approach in mouse embryonic stem cells: the lacZ reporter is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice; Mar. 26, 1992; pp. 903-918; Genes & Development.
Elizabeth Robertson, Allan Bradley, Michael Kuehn & Martha Evans; Germ-li
Lathe Richard Frank
Mountford Peter Scott
Smith Austin Gerard
Angell Jon Eric
Falk Anne-Marie
The University of Edinburgh
Tucker Ellis & West LLP
LandOfFree
Expression of heterologous genes according to a targeted... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Expression of heterologous genes according to a targeted..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Expression of heterologous genes according to a targeted... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3692906