Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1999-08-16
2000-10-31
Carlson, Karen Cochrane
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 698, 4353201, 435325, 4352523, 536 231, 530350, C12P 2106, C07H 1700, C07K 1400
Patent
active
061400823
ABSTRACT:
An expression system for expressing gene products from recombinant Bordetella strains and specific nucleic acid molecules useful in transforming Bordetella strains for such expression are described. A nucleic acid molecule may comprise a Bordetella promoter operatively coupled to a heterologous gene encoding a non-Bordetella gene product with the heterologous gene transcriptionally regulated by the Bordetella promoter. The nucleic acid molecule may further comprise a further nucleic acid molecule encoding a leader sequence for secretion of the non-Bordetella gene product. Another nucleic acid molecule may comprise a Bordetella promoter coupled to a nucleic acid sequence encoding a non-Bordetella leader sequence for secretion of a gene product, which may be a Bordetella gene product or a non-Bordetella gene product.
REFERENCES:
patent: 5395764 (1995-03-01), Riboli et al.
patent: 5439810 (1995-08-01), Loosemore et al.
patent: 5942418 (1999-08-01), Loosmore et al.
Johnson and Burns. 1994. J. Bacteriol. 176: 5350.
Loct et al. 1992. EMBO J. 11: 3175.
Zealey et al. 1992. Appl. Environ. Microbiol. 58: 208.
Burnette. 1994. Structure 2: 151.
Holmgren el al. 1993. Vaccine 11: 1179.
Wu and Russell. 1994. Vaccine 12: 215.
Dertzbough and Elson. 1993. Infect. Immun. 61: 384.
Cardenas and Clement. 1993. Vaccine 11: 126.
Airaksinen et al. 1991. Biotechnology Lett 13: 305.
Lebens et al. 1993. Bio/Technology 11: 1574.
Burnette et al. 1991. Infect. Immun. 59: 4266.
Klauser et al. 1990. EMBO J. 1991.
Nicosia et al. 1986. Proc. Natl. Acad. Sci. (USA)83: 4631.
Loosmore et al. 1989. Nucleic Acid Res. 17: 8365.
Relman et al. 1989. Proc. Natl. Acad. Sci. (USA)86: 2637.
Charles et al. 1989. Proc. Natl. Acad. Sci. (USA)86: 3554.
Dams et al. 1991. Biochen. Biophys. Acta. 1090: 139.
Zealey et al. 1990. Bio/Technology 8: 1025.
Imaizumi et al. 1983. Infect. Immun. 41: 1138.
Nicosia et al. 1987. Infect. Immun. 55: 963.
Makoff et al. 1990. Bio/Technology 8: 1030.
Domenighimi et al. 1990. Molec. Microbiol. 4: 787.
Watson, M. 1984. Nucl. Acids. Res. 12: 5145.
Gross et al 1992. Res Microbiol 143:671.
Scarlato et al 1991. Mol. Microbiol 5:2493.
Li et al 1991. Mol. Microbiol 5:409.
Stibitz et al 1986. Gene 50:133.
Bennetzen et al 1982. J. Biol Chem. 257:3026.
Goodey et ak 1986. Mol. Gen. Genet 204:505.
Kurosky et al 1997. J. Biol. Chem. 252:7257.
Klein Michel Henri
Loosmore Sheena M.
Yacoob Reza Khayyam
Zealey Gavin Ross
Carlson Karen Cochrane
Connaught Laboratories Limited
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