Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2005-09-09
2011-10-04
Ketter, Jim (Department: 1636)
Chemistry: molecular biology and microbiology
Vector, per se
C435S069600, C536S023500
Reexamination Certificate
active
08030065
ABSTRACT:
Two mechanisms are provided for improving the expression of Factor IX in gene therapy vectors. The first is the use of a specific Factor IX polynucleotide coding sequence designed for optimal expression. The second is the use of transcriptional regulatory regions minimized in size so that they can be used to express Factor IX, as well as any other gene of interest, in a size-constrained environment such as in a self complementary gene therapy vector system.
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Alston & Bird LLP
Ketter Jim
St. Jude Children's Research Hospital
LandOfFree
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