Chemistry: molecular biology and microbiology – Vector – per se
Patent
1988-08-08
1990-12-11
Martinell, James
Chemistry: molecular biology and microbiology
Vector, per se
435 693, 435 711, 4351723, 435255, 435256, 935 34, 935 37, 935 69, C12N 1500, C12N 116, C12N 118, C12P 2100
Patent
active
049770926
ABSTRACT:
Novel yeast cell transformation vectors are manufactured and employed in securing expression of exogenous polypeptides in yeast cells. Vectors include promoter/regulator DNA sequences of yeast glyceraldehyde-3-phosphate dehydrogenase gene origins. In an illustrative preferred embodiment, novel immunologically active hepatitis B surface antigen (HBsAg) preparations are isolated from yeast cells transformed with plasmid A.T.C.C. 40053. These HBsAg preparations of yeast origin may be incorporated into vaccine compositions useful in developing immunological responses protective against infection by hepatitis B virus.
REFERENCES:
patent: 4446235 (1984-05-01), Seeburg
patent: 4599311 (1986-07-01), Kawasaki
patent: 4615974 (1986-10-01), Kingsman et al.
patent: 4769238 (1988-09-01), Rutter et al.
patent: 4803164 (1989-02-01), Hitzeman et al.
Valenzuela et al., "Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen", Nature 280:815 (1979).
Botstein et al., "Sterile host yeasts(SHY): A eukaryotic System of biological containment for recombinant DNA experiments", Recombinant DNA Technical Bulletin 2 (2): 49 (1979).
Holland et al., "Isolation and characterization of a gene coding for glyceraldehyde-3-phosphate dehydrogenase from Saccharomyces cerevisiae", J. Biol. Chem. 254: 5466 (1979).
Holland et al., "The primary structure of a glyceraldehyde-3-phosphate dehydrogenase gene from Saccharomyces cerevisiae", J. Biol. Chem. 254: 9839 (1979).
Holland et al., "Structural comparison of two nontandemly repeated yeast glyceraldeyde-3-phosphate dehydrogenase genes", J. Biol. Chem. 255: 2596 (1980).
Ammerer et al.: in Recombinant DNA, Walton (ed.), Elsevier Scientific Publishing Co., New York, 1981, pp. 185-197.
Grantham et al., "Codon frequencies in 119 individual genes confirm consistent choices of degenerate bases according to genome type", Nucleic Acids. Research 8(9), 1893 (1980).
Beggs, Nature, 275: 104-109 (1979).
Bennetzen et al., J. Biol. Chem., 257: 3018-3025 3026-3031 (1982).
Dreesman et al., Nature, 295: 158-160 (1982).
Edman et al., Nature, 291: 503-506 (1981).
Grantham et al., Nucleic Acids Research, 8: r49-r62 (1980).
Grantham et al., Nucleic Acids Research, 9: r43-r74 (1981).
Hall et al., DNA, 2: 182 (1982).
Hinnen et al., Proc. Natl. Acad. Sci. USA, 75: 1929-1933 (1978).
Hitzeman et al., J. Biol. Chem., 255: 12073-12080 (1980).
Hitzeman et al., Nature, 293: 717-722 (1982).
Hsiao et al., Proc. Natl. Acad. Sci. USA, 76: 3829-3833 (1979).
Kingsman et al., Gene, 7: 141-153 (1979).
Stinchcomb et al., Nature, 282: 39-43 (1979).
Stinchcomb et al., Proc. Natl. Acad. Sci. USA, 77: 4559 (1980).
Struhl et al., Proc. Natl. Acad. Sci. USA, 76: 1035-1039 (1979).
Valenzuela et al., Nature, 298: 347-350 (Jul. 1982).
Zaret et al., Cell, 28: 563-573 (1982).
"BRL Restriction Endonuclease Reference Chart" in the '81/'82 Catalog of Bethesda Research Laboratories, Inc., Gaithersburg, MD.
Musti et al., Gene, 25: 133-143 (1983).
Holland et al., J. Biol. Chem., 258(8): 5291-5299 (Apr. 1983).
Amgen
Martinell James
LandOfFree
Expression of exogenous polypeptides and polypeptide products in does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Expression of exogenous polypeptides and polypeptide products in, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Expression of exogenous polypeptides and polypeptide products in will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-389883