Expression of exogenous polynucleotide sequences cardiac muscle

Details Expression of exogenous polynucleotide sequences cardiac muscle Expression of exogenous polynucleotide sequences cardiac muscle

1995-06-07

1997-12-02

Crouch, Deborah

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

735 53, 735 55, 735 56, 735 60, A61K 4800, C12N 1500

Patent

active

056936222

ABSTRACT:
The present invention provides a method for delivering a pharmaceutical polypeptide to the interior of a cardiac cell of a vertebrate in vivo, comprising the step of introducing a preparation comprising a pharmaceutically acceptable injectable carrier and naked polynucleotide operatively coding for the polypeptide into the interstitial space of the heart, whereby the naked polynucleotide is taken up into the interior of the cell and has a pharmacological effect on the vertebrate. In a preferred embodiment wherein the polynucleotide encodes polypeptide immunologically foreign to the vertebrate, the delivery method preferably comprises delivering an immunosuppressive agent to the vertebrate to limit immune responses directed to the polypeptide.

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