Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1995-06-07
1998-05-26
Rories, Charles C.P.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435 691, 435 911, 4351721, 4351723, 4353201, 435377, 424450, 514 44, 536 241, 12820014, C12N 1587, A61K 912, A61K 4900, A61K 9127
Patent
active
057563535
ABSTRACT:
Methods for the delivery of genes directly to the lungs are disclosed. Liposome-nucleic acid complexes are delivered via aerosol with the subsequent in viva expression of a protein encoded by the delivered gene. The invention provides a convenient method for treating pulmonary disorders, as well as for delivering substances systemically via the lung.
REFERENCES:
patent: 3826255 (1974-07-01), Havstad
patent: 4394448 (1983-07-01), Szoka
patent: 4804678 (1989-02-01), Augstein
patent: 4946787 (1990-08-01), Eppstein
patent: 5032407 (1991-07-01), Wagner
patent: 5049386 (1991-09-01), Eppstein
patent: 5075229 (1991-12-01), Hanson
patent: 5240842 (1993-08-01), Mets
patent: 5240846 (1993-08-01), Collins
patent: 5264618 (1993-11-01), Felgner et al.
Dzau, Victor J., et al. (1993) "Gene therapy for cardiovascular disease", Tibtech 11:205-210.
Friedmann, Theodore (1989) "Progress Toward Human Gene Therapy", Science 244:1275-1281.
Zhu, Ning, et al., (1993) "Systemic Gene Expression After Intravenous DNA Delivery into Adult Mice", Science, 261:209-211.
Rosenfeld, et al. (1992) "In vivo Transfer of the Human Cystic Fibrosis Transmembrane Conductance Regulator Gene to the Airway Epithelium", Cell, 68:143-155.
Alton, E., et al. (1993) "Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice", Nature Genetics, 5:135-142.
Papahadjopoulos, et al., (1975) "Cochleate Lipid Cylinders: Formation by Fusion of Unilamellar Lipid Vesicles," Biochimica et Biophysica Acta, 394:483-491.
Deamer, et al., (1976) "Large Volume Liposomes by an Ether Vaporization Method", Biochimica et Biophysica Acta , 443:629-634.
Ostro, et al., (1977) "Incorporation of High Molecular Weight RNA into Large Artificial Lipid Vesicles", Biochemical and Biophysical Research Communications, 76(3):836-842.
Enoch, et al., (1979) "Formation and Properties of 1000-.ANG.-Diameter, Single-Bilayer Phospholipid Vesicles", PNAS (USA), 76(1):145-149.
Wilson, et al., (1979) "The Introduction of Poliovirus RNA into Cells via Lipid Vesicles (Lipsomes)", Cell, 17:77-84.
Fraley, et al., (1979) "Entrapment of a Bacterial Plasmid in Phospholipid Vesicles: Potential for Gene Transfer", PNAS (USA), 76(7):3348-3352.
Leserman, et al., (1980) "Targeting to Cells of Fluorescent Liposomes Covalenty Coupled wth Monoclonal Antibody or Protein A", Nature, 288:602-604.
Beaucage, et al., (1981) "Deoxynucleoside Phosphoramidites--A New Class of key Intermediates for Deoxypolynucleotide Synthesis", Tetrahedron Letters, 22(20):1859-1862.
Duckworth, et al. (1981) "Rapid Synthesis of Oligodeoxyribonucleotides VI. Efficient, Mechanised Synthesis of Heptadecadeoxyribonucleotides by an Improved Solid Phase Phosphotriester Route", Nucleic Acids Research, 9(7):1691-1706.
Martin, et al. (1981) "Immunospecific Targeting of Liposomes to Cells: A Novel and Efficient Method for Covalent Attachment of Fab' Fragments via Disulfide Bonds", Biochemistry, 20:4229-4238.
Matteucci, et al. (1981) "Synthesis of Deoxyoligonucleotides on a Polymer Support," J. Am. Chem. Soc., 103:3185-3191.
Volloch, et al. (1981) "Stability of Globin mRNA in Terminally Differentiating Murine Erythroleukemia Cells," Cell, 23:509-514.
Bothwell, et al. (1981) "Heavy Chain Variable Region Contribution to the NP.sub.b Family of Antibodies: Somatic Mutation Evident in a .gamma.2a Variable Region," Cell, 24:625-637.
Edge, et al. (1981) "Total Synthesis of a Human Leukocyte Interferon Gene," Nature, 292:756-762.
Schaefer-Ridder, et al. (1981) "Lipsomes as Gene Carriers: Efficient Transformation of Mouse L Cells by Thymidine Kinase Gene," Science, 215(8):166-168.
Gorman, et al. (1982) "Recombinant Genomes which Express Chloramphenicol Acetyltransferase in Mammalian Cells," Molecular and Cellular Biology 2(2):1044-1051.
Gorman, et al. (1982) "The Rous Sarcoma Virus Long Terminal Repeat is a Strong Promoter when Introduced into a Variety of Eukaryotic Cells by DNA-Mediated Transfection," PNAS (USA), 79:6777-6781.
Long, et al. (1984) "Complete Sequence of the cDNA for Human .alpha..sub.1 -Antitrypsin and the Gene for the S Variant," Biochemistry, 23:4828-4837.
Nambiar, et al. (1984) "Total Synthesis and Cloning of a Gene Coding for the Ribonuclease S. Protein," Science 223:1299-1301.
Jay, et al. (1984) "Chemical Synthesis of a Biologically Active Gene for Human Immune Interferon-.gamma.," Journal of Biological Chemistry, 259(10):6311-6317.
Kunkel, Thomas (1985) "Rapid and efficient site-specific mutagenesis without phenotypic selection," PNAS (USA), 82:488-492.
Boshart, et al. (1985) "A very Strong Enhancer is Located Upstream of an Immediate Early Gene of Human Cytomegalovirus," Cell, 41:521-530.
Stinski, et al. (1985) "Activation of the Major Immediate Early Gene of Human Cytomegalovirus by cis-Acting Elements in the Promoter-Regulatory Sequence and by Virus-specific trans-acting Components," Journal of Virology, 55(2):431-441.
Cullen, B.R. (1986) "Trans-Activation of Human Immunodeficiency Virus Occurs via a Bimodal Mechanism," Cell, 46:973-982.
Benvenisty, et al. (1986) "Direct introduction of genes into rats and expression of the genes," PNAS (USA), 83:9551-9555.
Wang, et al. (1987) "pH Sensitive Immunoliposomes Mediate Target-Cell-Specific Delivery and Controlled Expression of a Foreign Gene in a Mouse," PNAS (USA), 84:7851-7855.
Sakai, et al. (1988) "Hormone-Mediated Repression: A Negative Glucocorticoid Response Element from the Bovine Prolactin Gene," Genes and Development, 2:1144-1154.
Stamatatos, et al. (1988) "Interactions for Cationic Lipid Vesicles with Negatively Charged Phospholipid Vesicles and Biological Membranes", Biochemistry, 27:3917-3925.
Wu, et al. (1988) "Receptor-Mediated Gene Delivery and Expression In Vivo," J. Biological Chemistry, 263(29):14621-14624.
Kaneda, et al. (1989) "Increased Expression of DNA Cointroduced with Nuclear Protein in Adult Rat Liver," Science 243:375-378.
Rommens, et al. (1989) "Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping," Science, 245:1059-1065.
Goodfellow, P.N. (1989) "Steady Steps Lead to the Gene," Nature, 341:102-103.
Mizuno, et al. (1989) "In Vitro and In Vivo Expression of Human Interferon-.beta. in Glioma Cells Transfected with its Gene Encapsulated in Liposomes," J. Interferon Research, 9, Supp. 2:S151 (Abstract Al-8).
Huang, et al. (1990) "Intervening Sequences Increase Efficiency of RNA 3'Processing and Accumulation of Cytoplasmic RNA," Nucleic Acids Research, 18(4) :937-947.
Ono, et al. (1990) "Plasmid DNAs Directly Injected into Mouse Brain with Lipofectin Can Be Incorporated and Expressed by Brain Cells," Neuroscience Letters, 117:259-263.
Holt, et al. (1990) "Lipofection of cDNAs in the Embryonic Vertebrate Central Nervous System," Neuron, 4:203-214.
Uhlman, et al. (1990) "Antisense Oligonucleotides: A New Therapeutic Principle," Chemical Reviews, 90(4):543-584.
Crystal, R.G. (1990) ".alpha.1-Antitrypsin Deficiency, Emphysema, and Liver Disease", The Journal of Clinical Investigation, Inc., 85:1343-1352.
Shyu, Ann-Bin, et al. (1989) "The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways", Genes & Development, 3:60-72.
Rosenberg, et al. (1990) "Gene Transfer into Humans--Immunotherapy of Patients with Advanced Melanoma, Using Tumor-Infiltrating Lymphocytes Modified by Retroviral Gene Transduction", The New England Journal of Medicine, 323(9):570-578.
Burhans, et al. (1990) "Identification of an Origin of Bidirectional DNA Replication in Mammalian Chromosomes", Cell. 62:955-965.
Verma (1990) "Gene Therapy: Treatment of disease by introducing healthy genes into the body is becoming feasible. But the therapy will not reach its full potential until the genes can be coaxed to work throughout life", Scientific American, 68-84.
Barr, et al. (1991) "Expression of Recombinant Genes in Myocardium In Vivo Following Direct Injection of DNA", Clinical Research, 39:2:152A.
Kitsis, et al. (1991) "Behaviour of Genes Directly Transferred to Rat Heart In Vivo", Clinical Research, 39:2:152A.
Palmiter, et al. (1991) "Heterologous introns can enhanc
Rories Charles C.P.
The Regents of the University of California
LandOfFree
Expression of cloned genes in the lung by aerosol-and liposome-b does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Expression of cloned genes in the lung by aerosol-and liposome-b, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Expression of cloned genes in the lung by aerosol-and liposome-b will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1959192