Expression of a tumor-specific antigen by a recombinant vector v

Details Expression of a tumor-specific antigen by a recombinant vector v Expression of a tumor-specific antigen by a recombinant vector v

1997-12-12

1999-12-28

Degen, Nancy

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 936, 4352351, 4353201, A01N 6300, C12N 1586, C12N 701, C12N 704

Patent

active

060078065

ABSTRACT:
The invention concerns a vector being vaccinia virus, which comprises a heterologous DNA sequence which codes at least for the essential region of a tumor specific protein called T antigen, cloned within a non essential region of the vaccinia virus, as well as regulatory element required for the expression of the DNA sequence in higher cells, the vector is particularly useful as a pharmaceutical composition having a preventive or creative activity against tumors especially tumors caused by a papillomavirus.

REFERENCES:
patent: 4603112 (1986-07-01), Paoletti
patent: 5744133 (1998-04-01), Lathe et al.
Rassoulzadegan et al., The roles of individual polyoma virus early proteins in oncogenic transformation, Nature, vol. 300, Dec. 23/30, 1982, pp. 713-718.
Tyndall et al., A region of the polyoma virus genome between the replication origin and late protein coding sequences is required in cis for both early gene expression and viral DNA replication, Nucleic Acids Research, vol. 9, No. 23, 1981, pp. 6231-6251.
Food and Drug Administration, HHS, 21 CFR Sections 620.1-620.33.
Treisman et al., Transformation of rat cells by an altered polyoma virus genome expressing only the middle-T protein, Nature, vol. 292, Aug. 13, 1981, pp. 595-600.
Cason et al., Toward Vaccines Against Human Papillomavirus type-16 Genital Infections, Vaccine, vol. 11, 603-611, 1993.

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