Expression of a protein in myocardium by injection of a gene

Details Expression of a protein in myocardium by injection of a gene Expression of a protein in myocardium by injection of a gene

1995-01-23

1997-08-26

Stone, Jacqueline M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4351723, A01N 4304, A61K 3170, C12N 1500

Patent

active

056611331

ABSTRACT:
A novel method for expressing a protein which comprises: transforming skeletal myoblasts or cardiac myocytes with a DNA sequence comprising a DNA segment encoding a selected gene downstream of the Rous sarcoma virus long terminal repeat or the expression sequence in pRSV, and implanting said skeletal myoblasts or cardiac myocytes into a recipient which then expresses a physiologically effective level of said protein.

REFERENCES:
Leslie A. Leinwant and JeffreyM. Leiden, Trends Cardiovase. Med. vol. 1, "Gene Transfer into Cardiac Myocytes In Vivo", pp. 271-276 (1991).
George Palade, Science vol. 189 pp. 347-357 "Intracellular Aspects of the PRocess of PRotein Synthesis". Aug. 1975.
Bloom and Fowell, A Textbook of Histology; Eleventh Edition, 1986 W.B. Sounders Co. p. 83, "Glands and Secretion; p. 279, Muscle Tissue".
R. Kitsis, P. Buttrick, E. McNally, M. Kaplan and L. Leinwand; "Hormonal Modulation of a Gene Injected Into Rat Heart in vivo" Proc. Natl. Acad. Sci. USA vol. 88, pp. 4138-4142 May 1991.
E. Barr and J. Leiden, Science "Systemic Delivery of Recombinant Proteins By Genetically Modified Myoblasts" vol. 254, Dec. 1991, pp. 1507-1509.
H. Lin M.D.; M. Parmacek, M.D.; G. Morle, BS; S. Bolling, M.D. and J. Leiden M.D. PH.D. Brief Rapid Communication, "Expression of Recombinant Genes in Myocardium In Vivo After Direct Injection of DNA" Circulation, vol. 82, No. 6. Dec. 1990 pp. 2217-2221.
J. Dhawan, L. Pan, G. Pavlath, M. Tavis, A. Lanctot and H. Blau; Science, vol. 254, Dec. 6, 1991 "Systemic Delivery of Human Growth Hormone By Injection of Genetically Engineered Myoblasts"; pp. 1509-1512.
G. Acsadi, S. Jiao, A. Jani, D. Duke, P. Williams, W. Chong and J. Wolff; The New Biologist, vol. 3, No. 1 (Jan.) 1991 pp. 71-81, "Direct Gene Transfer and Expression into Rat Heart In Vivo".
Buttrick et al., Circ. Res., vol. 70 No. 1, Jan. 1992, pp. 193-198.
Gorman et al. (1983), Science 221, 551-553.
Parmacek et al. (Sep. 1990), J. Biol. Chem. 265(26), 15970-15976.
Anderson et al. (1989), J. Cell. Biochem. (Suppl.) vol. 13 Part E, p. 176.
Partridge et al. (1989), Nature 337, 176-179.
Wolff et al. (Mar. 1990), Science 247, 1465-1468.

Affiliated with

Also associated with

Rating

Expression of a protein in myocardium by injection of a gene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Expression of a protein in myocardium by injection of a gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Expression of a protein in myocardium by injection of a gene will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1988605