Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-08-09
2005-08-09
Horlick, Kenneth R. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S281000, C435S281000, C536S023100, C536S024300
Reexamination Certificate
active
06927032
ABSTRACT:
This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm2, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.
REFERENCES:
patent: 3730844 (1973-05-01), Gilham et al.
patent: 4071315 (1978-01-01), Chateau
patent: 4327073 (1982-04-01), Huang
patent: 4373071 (1983-02-01), Itakura
patent: 4458066 (1984-07-01), Caruthers et al.
patent: 4483920 (1984-11-01), Gillespie et al.
patent: 4486539 (1984-12-01), Ranki et al.
patent: 4500707 (1985-02-01), Caruthers et al.
patent: 4542102 (1985-09-01), Dattagupta et al.
patent: 4556643 (1985-12-01), Paau et al.
patent: 4562157 (1985-12-01), Lowe et al.
patent: 4563419 (1986-01-01), Ranki et al.
patent: 4584277 (1986-04-01), Ullman et al.
patent: 4591570 (1986-05-01), Chang
patent: 4613566 (1986-09-01), Potter
patent: 4670380 (1987-06-01), Dattagupta
patent: 4677054 (1987-06-01), White et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4689405 (1987-08-01), Frank
patent: 4704353 (1987-11-01), Humphries et al.
patent: 4711955 (1987-12-01), Ward et al.
patent: 4716106 (1987-12-01), Chiswell
patent: 4728591 (1988-03-01), Clark et al.
patent: 4731325 (1988-03-01), Palva et al.
patent: 4755458 (1988-07-01), Rabbani et al.
patent: 4767700 (1988-08-01), Wallace
patent: 4780504 (1988-10-01), Buendia et al.
patent: 4812512 (1989-03-01), Buendia et al.
patent: 4820630 (1989-04-01), Taub
patent: 4833092 (1989-05-01), Geysen
patent: 4849513 (1989-07-01), Smith et al.
patent: 4855225 (1989-08-01), Fung et al.
patent: 4868103 (1989-09-01), Stavrianopoulos et al.
patent: 4868104 (1989-09-01), Kurn et al.
patent: 4868105 (1989-09-01), Urdea et al.
patent: 4874500 (1989-10-01), Madou et al.
patent: 4921805 (1990-05-01), Gebeyehu et al.
patent: 4923901 (1990-05-01), Koester et al.
patent: 4925785 (1990-05-01), Wang et al.
patent: 4981783 (1991-01-01), Augenlicht
patent: 4987065 (1991-01-01), Stavrianopoulos et al.
patent: 4988617 (1991-01-01), Landegren et al.
patent: 4992383 (1991-02-01), Farnsworth
patent: 4994373 (1991-02-01), Stavrianopoulos et al.
patent: 5002867 (1991-03-01), Macevicz
patent: 5013669 (1991-05-01), Peters, Jr. et al.
patent: 5021550 (1991-06-01), Zeiger
patent: 5026840 (1991-06-01), Dattagupta et al.
patent: 5028525 (1991-07-01), Gray et al.
patent: 5028545 (1991-07-01), Soini
patent: 5043265 (1991-08-01), Tanke et al.
patent: 5047524 (1991-09-01), Andrus et al.
patent: 5064754 (1991-11-01), Mills
patent: 5082830 (1992-01-01), Brakel et al.
patent: 5091652 (1992-02-01), Mathies et al.
patent: 5100777 (1992-03-01), Chang
patent: 5141813 (1992-08-01), Nelson
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5153319 (1992-10-01), Caruthers et al.
patent: 5173260 (1992-12-01), Zander et al.
patent: 5185243 (1993-02-01), Ullman et al.
patent: 5188963 (1993-02-01), Stapleton
patent: 5200051 (1993-04-01), Cozzette
patent: 5200312 (1993-04-01), Oprandy
patent: 5202231 (1993-04-01), Drmanac et al.
patent: 5204268 (1993-04-01), Matsumoto
patent: 5215882 (1993-06-01), Bahl et al.
patent: 5232829 (1993-08-01), Longiaru et al.
patent: 5242974 (1993-09-01), Holmes
patent: 5252296 (1993-10-01), Zuckermann et al.
patent: 5252743 (1993-10-01), Barrett et al.
patent: 5256549 (1993-10-01), Urdea
patent: 5310893 (1994-05-01), Erlich et al.
patent: 5328824 (1994-07-01), Ward et al.
patent: 5338688 (1994-08-01), Deeg et al.
patent: 5348855 (1994-09-01), Dattagupta et al.
patent: 5389512 (1995-02-01), Kwok et al.
patent: 5412087 (1995-05-01), McGall et al.
patent: 5422241 (1995-06-01), Goldrick et al.
patent: 5434049 (1995-07-01), Okano et al.
patent: 5436327 (1995-07-01), Southern et al.
patent: 5445934 (1995-08-01), Fodor et al.
patent: 5447841 (1995-09-01), Gray et al.
patent: 5472842 (1995-12-01), Stokke et al.
patent: 5474796 (1995-12-01), Brennan
patent: 5474895 (1995-12-01), Ishii et al.
patent: 5486452 (1996-01-01), Gordon et al.
patent: 5489507 (1996-02-01), Chehab
patent: 5492806 (1996-02-01), Drmanac et al.
patent: 5501954 (1996-03-01), Mahr et al.
patent: 5510270 (1996-04-01), Fodor et al.
patent: 5512430 (1996-04-01), Gong
patent: 5514543 (1996-05-01), Grossman et al.
patent: 5514785 (1996-05-01), Van Ness et al.
patent: 5516641 (1996-05-01), Ullman et al.
patent: 5518883 (1996-05-01), Soini
patent: 5525464 (1996-06-01), Drmanac et al.
patent: 5545531 (1996-08-01), Rava et al.
patent: 5556748 (1996-09-01), Douglas
patent: 5556752 (1996-09-01), Lockhart et al.
patent: 5563060 (1996-10-01), Hozier
patent: 5571639 (1996-11-01), Hubbell et al.
patent: 5578832 (1996-11-01), Trulson et al.
patent: 5605662 (1997-02-01), Heller et al.
patent: 5667972 (1997-09-01), Drmanac et al.
patent: 5690894 (1997-11-01), Pinkel et al.
patent: 5695940 (1997-12-01), Drmanac et al.
patent: 5700637 (1997-12-01), Southern et al.
patent: 5744305 (1998-04-01), Fodor
patent: 5807522 (1998-09-01), Brown
patent: 5830645 (1998-11-01), Pinkel et al.
patent: 5837832 (1998-11-01), Chee et al.
patent: 5972619 (1999-10-01), Drmanac et al.
patent: 6018041 (2000-01-01), Drmanac et al.
patent: 6025136 (2000-02-01), Drmanac et al.
patent: 6040138 (2000-03-01), Lockhart et al.
patent: 6309822 (2001-10-01), Fodor et al.
patent: 6410229 (2002-06-01), Lockhart et al.
patent: 6548257 (2003-04-01), Lockhart et al.
patent: 3505287 (1985-09-01), None
patent: 063 810 (1982-10-01), None
patent: 171 150 (1986-02-01), None
patent: 173 339 (1986-03-01), None
patent: 185 547 (1986-06-01), None
patent: 225 807 (1987-06-01), None
patent: 232 967 (1987-08-01), None
patent: 235 726 (1987-09-01), None
patent: 237 362 (1987-09-01), None
patent: 281 927 (1988-09-01), None
patent: 337 498 (1989-10-01), None
patent: 392 546 (1990-10-01), None
patent: 535 242 (1993-07-01), None
patent: 717 113 (1996-06-01), None
patent: 721 016 (1996-07-01), None
patent: 2559783 (1985-02-01), None
patent: 2156074 (1985-10-01), None
patent: 63-223557 (1989-09-01), None
patent: WO 84/03151 (1984-08-01), None
patent: WO 85/01051 (1985-03-01), None
patent: WO 89/10977 (1989-11-01), None
patent: WO 90/00626 (1990-01-01), None
patent: WO 91/12603 (1990-01-01), None
patent: WO 90/03382 (1990-04-01), None
patent: WO 90/04652 (1990-05-01), None
patent: WO 90/15070 (1990-12-01), None
patent: WO 92/10092 (1992-06-01), None
patent: WO 92/10588 (1992-06-01), None
patent: WO 93/04199 (1993-03-01), None
patent: WO 93/11262 (1993-06-01), None
patent: WO 93/17126 (1993-09-01), None
patent: WO 93/22680 (1993-11-01), None
patent: WO 94/11530 (1994-05-01), None
patent: WO 95/00530 (1995-01-01), None
patent: WO 95/04594 (1995-02-01), None
patent: WO 95/04833 (1995-02-01), None
patent: WO 95/04834 (1995-02-01), None
patent: WO 95/11995 (1995-05-01), None
patent: WO 95/15970 (1995-06-01), None
patent: WO 95/20681 (1995-08-01), None
patent: WO 95/21944 (1995-08-01), None
patent: WO 95/25116 (1995-09-01), None
patent: WO 95/30774 (1995-11-01), None
patent: WO 95/35505 (1995-12-01), None
patent: WO 96/17958 (1996-06-01), None
patent: WO 97/10365 (1997-03-01), None
patent: WO 98/31836 (1998-07-01), None
patent: WO 89/11548 (1998-11-01), None
Augenlicht et al., “Cloning and Screening of Sequences Expressed in a Mouse Colon Tumor,”Cancer Research
Brown Eugene L.
Chee Mark
Gingeras Thomas R.
Lockhart David J.
Wong Gordon G.
Affymetrix Inc.
Horlick Kenneth R.
Townsend and Townsend / and Crew LLP
LandOfFree
Expression monitoring by hybridization to high density... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Expression monitoring by hybridization to high density..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Expression monitoring by hybridization to high density... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3504060