Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-04-07
1997-12-30
Low, Christopher S.F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 221, 536 231, 536 232, 536 234, 536 235, 536 2351, 536 2372, 536 2374, 536 237, 435325, 4353201, 4351723, 4351721, 435 6, 435 71, 424422, 424423, 424 92, A01N 4304
Patent
active
057030570
ABSTRACT:
A general method for vaccinating against any pathogen is presented. The method utilizes expression library immunization, where an animal is inoculated with an expression library constructed from fragmented genomic DNA of the pathogen. All potential epitopes of the pathogen's proteins are encoded in its DNA, and genetic immunization is used to directly introduce one or more expression library clones to the immune system, producing an immune response to the encoded protein. Inoculation of expression libraries representing portions of the Mycoplasma pulmonis genome was shown to protect mice from subsequent challenge by this natural pathogen. Protection against Listeria was also obtained using the method.
REFERENCES:
patent: 5451399 (1995-09-01), Gimbrone, Jr. et al.
patent: 5589466 (1996-12-01), Felgner et al.
Ada, "Strategies for Exploring the Immune System in the Design of Vaccines," Molecular Immunology, 28(3):225-230, 1991.
Ausebel et al., "Short Protocols in Molecular Biology," Second Edition, A Compendium of Methods from Current Protocols in Molecular Biology.
Barry et al., "Production of Monoclonal Antibodies by Genetic Immunization," BioTechniques, 16(4):616-620, 1994.
Coney et al., "Facilitated DNA inoculation induces anti-HIV-1 immunity in vivo, " Vaccine, 12(16):1545-1550, 1994.
Conry et al., "Immune Response to a Carcinoembryonic Antigen Polynucleotide Vaccine," Cancer Research, 54:1164-1168, Mar. 1994.
Cox et al., "Bovine Herpesvirus 1: Immune Responses in Mice and Cattle Injected with Plasmid DNA," Journal of Virology, 67(9):5664-5667, Sep. 1993.
Davis et al., "DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody," Human Molecular Genetics, 2:(11)1847-1851, 1993.
Eisenbraun et al., "Examination of Parameters Affecting the Elicitation of Humoral Immune Responses by Particle Bombardment-Mediated Genetic Immunization," DNA and Cell Biology, 12(9):791-797, 1993.
Fynan et al., "DNA vaccines: Protective immunizations by parenteral, mucosal, and gene-gun inoculations," Proc. Natl. Acad. Sci. Usa, 90:11478-11482, Dec., 1993.
Kovacsovics-Bankowski et al., "Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages," Proc. Natl. Acad. Sci. USA, 90:4942-4946, Jun., 1993.
Lai et al., "Protection of mice against experimental murine mycoplasmosis by a Mycoplasma pulmonis immunogen in lysogenized Escherichia coli," Vaccine, 12(4):291-298, 1994.
Lowrie et al., "Towards a DNA vaccine against tuberculosis," Vaccine, 12(16):1537-1540, 1994.
Tang et al., "Genetic immunization is a simple method for eliciting an immune response," Nature, 356:152-154, Mar., 1992.
Ulmer et al., "Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein," Science, 259:1745-1749, Mar., 1993.
Wang et al., "Gene inoculation generates immune responses against human immunodeficiency virus type 1," Proc. Natl. Acad. Sci. USA, 90:4156-4160, May, 1993.
Xiang et al., "Vaccination with a Plasmid Vector Carrying the Rabies Virus Glycoprotein Gene Induces Protective Immunity against Rabies Virus," Virology, 199:132-140, 1994.
Crystal, R. G. 1995 Science 270: 404-409.
Warner et al. 1995 Annals of the New York Academy of Sciences 772: 105-116.
Wang et al. 1995 Annals of the New York Academy of Sciences 772: 186-197.
Barry et al. 1995 Nature 377: 632-635.
Klein, J. 1982. in: Immunology, The Science of Self-Nonself Discrimination, John Wiley & Sons. New York, pp. 6-9, 660-661.
Stryer, L. 1975. in: Biochemistry, Wilt. Freeman and Co., San Francisco p. 732.
Webster's II. New Riverside University Dictionary, (Soukhanov et al., eds.), 1984, The Houghton Mifflin Co., Boston, MA. p. 67.
Asabel et al. (eds.) 1988. in: Cunent Protocols in Molecular Biology, John Wiley and Sons, New York, pp. 6.0.3-6.0.4.
Barry Michael A.
Johnston Stephen A.
Lai Wayne C.
Board of Regents , The University of Texas System
Low Christopher S.F.
LandOfFree
Expression library immunization does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Expression library immunization, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Expression library immunization will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-202331