Expression control sequences of the P-selectin gene

Details Expression control sequences of the P-selectin gene Expression control sequences of the P-selectin gene

1993-08-20

1997-02-25

Campell, Bruce R.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 691, 4353201, 435325, 435366, 435367, 435371, 435372, 435365, 536 231, 536 235, 536 241, 536 2431, 935 16, 935 23, 935 34, C12N 1500, C07H 2104

Patent

active

056058217

ABSTRACT:
DNA molecules and methods for the regulated expression of a gene in endothelial cells or megakaryocytes, are described, wherein the 5' flanking region of the P-selectin gene, or portions thereof, is ligated to the 5' end of a gene. The DNA molecules are also used as probes for screening individuals with abnormal levels of expression of P-selectin, or for production of pharmaceutical compositions to inhibit inflammation by inhibition of expression of P-selectin. These DNA molecules can also be used to identify and isolate previously unknown proteins which are involved in regulation of gene expression.

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