Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1994-06-02
1999-03-30
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 69, 536 235, C07K 14205, C12N 1512
Patent
active
058891501
ABSTRACT:
The present invention relates to a novel method, based on direct expression cloning, for identifying target proteins capable of binding to and/or serving as substrates for receptor or cytoplasmic tyrosine kinases. The present invention also relates to novel proteins identified using this method, and to methods for identifying compounds that disrupt the interaction of such novel proteins with the receptor or cytoplasmic tyrosine kinases.
REFERENCES:
patent: 4675285 (1987-06-01), Clark et al.
Cantley et al., 1991, "Oncogenes and Signal Transduction", Cell 64:281-302.
Carpenter and Cohen, 1990, "Epidermal Growth Factor", J. Biol. Chem. 265:7709-7712.
Clark et al., 1992, "Genes Involved in Two Caenorhabditis elegans Cell-Signaling Pathways", Cold Spring Harb. Symp. Quant. Biol. 57:363-373.
Coughlin et al., 1989, "Role of Phosphatidylinositol Kinase in PGDF Receptor Signal Transduction", Science, 243:1191-1194.
Gould and Hunter, 1988, "Platelet-Derived Growth Factor Induces Multisite Phosphorylation of pp60.sup.c-src and Increases Its Protein-Tyrosine Kinase Activity", Mol. Cell. Biol. 8:3345-3356.
Heldin, 1991, "SH2 Domains: Elements that Control Protein Interactions During Signal Transduction", TIBS 16:450-452.
Kaplan et al., 1990, "Cloning of Three Human Tyrosine Phosphatases Reveals a Multigene Family of Receptor-Linked Protein-Tyrosine-Phosphatases Expressed in Brain", Proc. Natl. Acad. Sci. USA 87:7000-7004.
Kaplan et al., 1987, "Common Elements in Growth Factor Stimulation and Oncogenic Transformation: 85 kd Phosphoprotein and Phosphatidylinositol Kinase Activity", Cell 50:1021-1029.
Kazlauskas and Cooper, 1990, "Phosphorylation of the PDGF Receptor .beta. Subunit Creates a Tight Binding Site for Phosphatidylinositol 3 Kinase", Embo J. 9:3279-3286.
Kazlauskas and Cooper, 1989, "Autophosphorylation of the PDGF Receptor in the Kinase Insert Region Regulates Interactions with Cell Proteins", Cell 58:1121-1133.
Kishimoto et al., 1985, "Studies on the Phosphorylation of Myelin Basic Protein by Protein Kinase C and Adenosine 3':5'-Monophosphate-Dependent Protein Kinase", J. Biol. Chem. 260:12492-12499.
Klee and Guerini, 1990, "Structure and Regulation of Calcineurin, a Calmodulin-Stimulated Protein Phosphatase", FASEB J. 4:A2172.
Koch et al., 1991, "SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins", Science 252:668-674.
Kuenzel et al., 1987, "Substrate Specificity Determinants for Casein Kinase II as Deduced from Studies with Synthetic Peptides", J. Biol. Chem. 262:9136-9140.
Kumjian et al., 1989, "Platelet-Derived Growth Factor (PDGF) Binding Promotes Physical Association of PDGF Receptor with Phospholipase C", Proc. Natl. Acad. Sci. USA 86:8232-8236.
Kypta et al., 1990, "Association Between the PDGF Receptor and Members of the src Family of Tyrosine Kinases", Cell 62:481-492.
Margolis, 1992, "Proteins with SH2 Domains: Transducers in the Tyrosine Kinase Signaling Pathway", Cell Growth and Differentiation 3:73-80.
Margolis, et al., 1992, "Tyrosine Phosphorylation of vav Proto-Oncogene Product Containing SH2 Domain and Transcription Factor Motifs", Nature 356:71-74.
Marin et al., 1986, "Site Specificity of Casein Kinase-2 (TS) from Rat Liver Cytosol. A Study with Model Peptide Substrates.", Eur. J. Biochem. 160:239-244.
Martin et al., 1992, "GAP Domains Responsible for Ras p21-Dependent Inhibition of Muscarinic Atrial K.sup.+ Channel Currents", Science 255:192-194.
McGlade et al., 1992, "SH2 Domains of the p85.alpha. Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors", Mol. Cell. Biol. 12:991-997.
Molloy et al., 1989, "PDGF Induction to Tyrosine Phosphorylation of GTPase Activating Protein", Nature 342:711-714.
Morrison et al., 1989, "Direct Activation of the Serine/Threonine Kinase Activity of Raf-1 Through Tyrosine Phosphorylation by the PDGF .beta.-Receptor", Cell 58:649-657.
Pawson, 1988, "Non-Catalytic Domains of Cytoplasmic Protein-Tyrosine Kinases: Regulatory Elements in Signal Transduction", Oncogene 3:491-495.
Reedijk et al., 1990, "Interactions of Phosphatidylinositol Kinase, GTPase-Activating Protein (GAP), and GAP-Associated Proteins with the Colony-Stimulating Factor-1 Receptor", Mol. Cell. Biol. 10:5601-5608.
Sap et al., 1990, "Cloning and Expression of a Widely Expressed Receptor Tyrosine Phosphatase", Proc. Natl. Acad. Sci. USA 87:6112-6116.
Shurtleff et al., 1990, "Structural Features of the Colony-Stimulating Factor 1 Receptor that Affect Its Association with Phosphatidylinositol 3-Kinase", EMBO J. 9:2415-2421.
Wahl et al., 1990, "Identification of Two Epidermal Growth Factor-Sensitive Tyrosine Phosphorylation Sites of Phospholipase-C-.gamma. in Intact HSC-1 Cells", J. Biol. Chem. 265:3944-3948.
Whitman et al., 1985, "Association of Phosphatidylinositol Kinase Activity with Polyoma Middle-T Competent for Transformation", Nature 315:239-242.
Williams, 1989, "Signal Transduction by the Platelet-Derived Growth Factor Receptor", Science 243:1564-1570.
Woodgett et al., 1986, "Substrate Specificity of Protein Kinase C. Use of Synthetic Peptides Corresponding to Physiological Sites as Probes for Substrate Recognition Requirements", Eur. J. Biochem. 161:177-184.
Lehmann et al., 1990, "Nck, a Melanoma cDNA Encoding a Cytoplasmic Protein Consisting of the src Homology Units SH2 and SH3", Nucl. Acids Res. 18:1048.
Matsuda et al., 1992, "Two Species of Human CRK cDNA Encode Proteins with Distinct Biological Activities", Mol. Cell. Biol. 12:3482-3489.
Reichman et al., 1992, "The Product of the Cellular crk Gene Consists Primarily of SH2 and SH3 Regions", Cell Growth & Differentiation 3:451-460.
Anderson et al., 1990, "Binding of SH2 Domains of Phospholipase C.gamma.1, GAP, and Arc to Activated Growth Factor Receptors", Science 250:979-982.
Cobb et al., 1989, "Autophosphorylation Activates the Soluble Cytoplasmic Domain of the Insulin Receptor in an Intermolecular Reaction", J. Biol. Chem. 264:18701-18706.
Ellis et al., 1990, "Phosphorylation of GAP and GAP-Associated Proteins by Transforming and Mitogenic Tyrosine Kinases", Nature 343:377-380.
Escobedo et al., 1991, "cDNA Cloning of a Novel 85kd Protein that has SH2 Domains and Regulates Binding of PI3-kinase to the PGDF .beta.-Receptor", Cell 65:75-82.
Kaplan et al., 1990, "PDGF .beta.-Receptor Stimulates Tyrosine Phosphorylation of GAP and Association of GAP with a Signaling Complex", Cell 61:125-133.
Kazlauskas et al., 1990, "Binding of GAP to Activated PDGF Receptors", Science 247:1578-1581.
King and Sale, 1988, "Assay of Phosphotyrosyl Protein Phosphatase Using Synthetic Peptide 1142-1153 of the Insulin Receptor", FEBS Lett. 237:137-140.
Krueger et al., 1990, "Structural Diversity and Evolution of Human Receptor-Like Protein Tyrosine Phosphatases", EMBO J. 9:3241-3252.
MacGregor et al., 1990, "Direct Cloning of Leucine Zipper Proteins: Jun Binds Cooperatively to the CRE with CRE-BP1", Oncogene 5:451-458.
Margolis et al., 1989, "EGF Induces Tyrosine Phosphorylation of Phospholipase C-II: A Potential Mechanism for EGF Receptor Signalling", Cell 57:1101-1107.
Margolis et al., 1990, "The Tyrosine Phosphorylated Carboxyterminus of the EGF Receptor is a Binding Site for GAP and PLC-.sub..gamma. ", EMBO J. 9:4375-4380.
Margolis et al., 1990, Tyrosine Kinase Activity is Essential for the Association of Phospholipase C-.sub..gamma. with the Epidermal Growth Factor Receptor, Mol. Cell. Biol. 10:435-441.
Margolis et al., 1990, "Effect of Phospholipase C-.sub..gamma. Overexpression of PDGF-Induced Second Messengers and Mitogenesis", Science 248:607-610.
Matsuda et al., 1990, "Binding of Transforming Protein P4.sup.gag-crk to a Broad Range of Phosphotyrosine-Containing Proteins" Science 248:1537-1539.
Mayer et al., 1988, "A Novel Viral Oncogene with Structural Similarity to Phospholipase C", Nature 332:272-275.
Mayer et al., 1990, "Association of the v-crk Oncogene Product with Phosphotyrosine-Containing Proteins and Protein Kinase Activity", Proc. Nat. Acad. Sci USA 87:2638-2642.
Meisenhelder et al., 1989, "Phospholipase C-.sub..gamma. is a Substrate for th
App Harald
Margolis Benjamin L.
Schlessinger Joseph
Skolnik Edward Y.
New York University Medical Center
Ulm John
LandOfFree
Expression-cloning method for identifying target proteins for eu does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Expression-cloning method for identifying target proteins for eu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Expression-cloning method for identifying target proteins for eu will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1216251