Expression and secretion of mature human beta interleukin-1 in B

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

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435 698, 4351723, 4353201, 435839, 536 241, C12N 121, C12N 1563, C12N 1567, C12N 1575

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057285713

ABSTRACT:
A new plasmid vector is described which can replicate in B. subtilis and which can express and secrete, in the culture medium, human beta interleukin-1 (beta IL-1) without amino acid sequences extraneous to the natural molecule, a strain of B. subtilis transformed by the vector and a method for the expression and secretion of mature human beta interleukin-1. The human beta interleukin-1 thus obtained shows a specific acitvity of 1.times.10.sup.9 U/mg of protein and is particularly suitable as a stimulant for the immune system, as an adjuvant in vaccines for the activation of the repair mechanism in cases of tissue damage, and for the treatment of auto-immune diseases in man.

REFERENCES:
patent: 5015574 (1991-05-01), Furutani et al.
A. Nakayama et al. "Processing of the Prepropeptide Portions of the Bacillus amyloliquefaciens Neutral Protease . . . " Journal of Biotechnology Sep. 3, 1991, pp. 55-69.
S.T. Motley et al. "Expression & Secretion of Human IL-1 in B. subtilis" Genetics & Biotechnology of Bacilli 2: 371-375 (1988).

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