Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-06-07
1995-08-01
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 698, 43525231, 4353201, 536 2352, 536 241, C07K 14545, C12N 121, C12N 1525, C12N 1575
Patent
active
054379881
ABSTRACT:
A new plasmid vector is described which can replicate in B.subtilis and which can express and secrete, in the culture medium, human beta interleukin-1 (beta IL-1) without amino acid sequences extraneous to the natural molecule, a strain of B.subtilis transformed by the vector and a method for the expression and secretion of mature human beta interleukin-1. The human beta interleukin-1 thus obtained shows a specific acitvity of 1.times.10.sup.9 U/mg of protein and is particularly suitable as a stimulant for the immune system, as an adjuvant in vaccines for the activation of the repair mechanism in cases of tissue damage, and for the treatment of auto-immune diseases in man.
REFERENCES:
patent: 5015574 (1991-05-01), Furutani et al.
Journal of Biotechnology, Processing of the Prepropeptide Portions of the Bacillus amyloliquefaciens Neutral Protease Fused to Bacillus subtilis .alpha.-amylase and Human Growth Hormone During Secretion in Bacillus subtilis, A. Nakayama, H. Shimada, Y. Furutani and M. Honjo, Sep. 3, 1991, pp. 55-69.
Motley, S. T. et al. "Expression & Secretion of Human IL-1 in B. subtilis," Genetics & Biotechnology of Bacilli, vol. 2, pp. 371-375 (1988).
Bellini Ada V.
Galli Giuliano
Grandi Guido
Lucchese Giuseppe
Eniricerche S.p.A.
Jacobson Dian C.
Wax Robert A.
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