Expression and purification of HIP/PAP and uses therefor

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S192100

Reexamination Certificate

active

07923014

ABSTRACT:
The present invention relates to methods of compositions comprising RegIII and HIP/PAP proteins, including the use of such proteins as diagnostic and therapeutic targets.

REFERENCES:
patent: 5110795 (1992-05-01), Hahn
patent: 5112856 (1992-05-01), Gaginella et al.
patent: 5216002 (1993-06-01), Gidda et al.
patent: 5238931 (1993-08-01), Yoshikawa et al.
patent: 5292771 (1994-03-01), Backstrom et al.
patent: 5312818 (1994-05-01), Rubin et al.
patent: 5324738 (1994-06-01), Dinan et al.
patent: 5331013 (1994-07-01), Ahlman et al.
patent: 5340801 (1994-08-01), Ewing et al.
patent: 5368854 (1994-11-01), Rennick
patent: 5391555 (1995-02-01), Marshall et al.
patent: 5552439 (1996-09-01), Panetta
patent: 5569680 (1996-10-01), Wu
patent: 5599795 (1997-02-01), McCann et al.
patent: 5604231 (1997-02-01), Smith et al.
patent: 5691343 (1997-11-01), Sandborn
patent: 5693645 (1997-12-01), Sharpe et al.
patent: 2005/0277593 (2005-12-01), Dieckgraefe et al.
Abergel et al., “Crystallization and preliminary crystallographic study of HIP/PAP, a human C-lectin overexpressed in primary liver cancers,”D. Biol. Crystallogr., 55(Pt 8):1487-1489, 1999.
Ayabe et al., “Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria,”Nat. Immunol., 1:113-8, 2000.
Bertrand et al., “Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation,”Embo J., 15:2678-2684, 1996.
Cash et al., “Refolding, purification, and characterization of human and murine RegIII proteins expressed inEscherichia coli,” Protein Expr. Purif., 48:151-159, 2006.
Christa et al., “HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells,”Am. J. Physiol., 271:G993-1002, 1996.
Christa et al., “High expression of the human hepatocarcinoma-intestine-pancreas/pancreatic-associated protein (HIP/PAP) gene in the mammary gland of lactating transgenic mice. Secretion into the milk and purification of the HIP/PAP lectin,”Eur. J. Biochem., 267:1665-1671, 2000.
Christa et al., “The human HIP gene, overexpressed in primary liver cancer encodes for a C-type carbohydrate binding protein with lactose binding activity,”FEBS Lett., 337:114-118, 1994.
Dieckgraefe et al., “Expression of the regenerating gene family in inflammatory bowel disease mucosa: Reg Ialpha upregulation, processing, and antiapoptotic activity,”J. Investig. Med., 50:421-434, 2002.
Ezekowitz, “Role of the mannose-binding lectin in innate immunity,”J. Infect. Dis., 187:S335-339, 2003.
Girardin et al., “Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan,”Science, 300:1584-7, 2003.
Hooper et al., “How host-microbial interactions shape the nutrient environment of the mammalian intestine,”Annu. Rev. Nutr., 22:283-307, 2002.
Inohara et al., “Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease,”J. Biol. Chem., 278:5509-12, 2003.
Keilbaugh et al., “Activation of RegIIIbeta/gamma and interferon gamma expression in the intestinal tract of SCID mice: an innate response to bacterial colonisation of the gut,”Gut., 54:623-629, 2005.
Livesey et al., “A Schwann cell mitogen accompanying regeneration of motor neurons,”Nature, 390:614-8, 1997.
Macpherson et al., “A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria,”Science, 288:2222-6, 2000.
Narushima et al., “Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma,”Gene, 185:159-168, 1997.
Ogawa et al., “Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution model,”Inflamm. Bowel Dis., 9:162-170, 2003.
Ogawa et al., “Identification of genes involved in mucosal defense and inflammation associated with normal enteric bacteria,”Am. J. Physiol. Gastrointest. Liver Physiol., 279:G492-499, 2000.
Pull et al., “Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury,”Proc. Natl. Acad. Sci. USA, 102:99-104, 2005.
Swidsinski et al., “Mucosal flora in inflammatory bowel disease,”Gastroenterology, 122:44-54, 2002.
Syder et al., “The impact of parietal cells onHelicobacter pyloritropism and host pathology: an analysis using gnotobiotic normal and transgenic mice,”Proc. Natl. Acad. Sci. USA, 100:3467-72, 2003.
Terazono et al., “A novel gene activated in regenerating islets,”J. Biol. Chem., 263:2111-2114, 1988.
Weis et al., “Structure of a C-type mannose-binding protein complexed with an oligosaccharide,”Nature, 360:127-134, 1992.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Expression and purification of HIP/PAP and uses therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Expression and purification of HIP/PAP and uses therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Expression and purification of HIP/PAP and uses therefor will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2656217

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.