Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1994-09-14
1996-07-30
Adams, Donald E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 698, 435 701, 4352401, 4352523, 4353201, 5303873, 5303911, 5303917, 530402, 530344, 530345, 536 231, 536 234, 536 2353, C07K 1646, C12N 1513, C12N 1511
Patent
active
055410871
ABSTRACT:
Disclosed are DNAs produced by recombinant techniques for inducing the expression and subsequent secretion of a target protein. The DNAs encode, in their 5' to 3' direction, a secretion cassette, including a signal sequence and an immunoglobulin Fc region, and a target protein. The DNAs can be transfected into a host cell for the expression, production and subsequent secretion of the target protein as a fusion protein. The secreted protein can be collected from the extracellular space, and further purified as desired. The secreted fusion protein additionally can be proteolytically cleaved to release the target protein from the secretion cassette.
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Gillies Stephen D.
Lo Kin-Ming
Sudo Yukio
Adams Donald E.
Fuji ImmunoPharmaceuticals Corporation
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