Expression and diagnostic use of pENV-3 encoded peptides which a

Details Expression and diagnostic use of pENV-3 encoded peptides which a Expression and diagnostic use of pENV-3 encoded peptides which a

1985-10-02

1988-11-15

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 7, 435 70, 436531, 436811, 530324, 530325, 530326, 530327, 530328, 530329, G01N 33545, G01N 3353, C12Q 170

Patent

active

047849410

ABSTRACT:
A method of expressing peptides which are immunologically reactive with antibodies to LAV is disclosed. The peptides are produced by bacterial host cells transformed with a recombinant plasmid which includes appropriate procaryotic transcriptional and translational signals for expression, followed by a DNA sequence coding for a peptide comprising the amino acid sequence as shown in FIG. 5 starting with isoleucine, number 1, and ending with threonine, number 173. The peptides of the present invention are immunologically reactive with antibodies to LAV, or antibodies to viruses defined to be the same as or equivalent to LAV. The peptides produced by the method disclosed may be used to screen for the presence of antibodies to LAV in a biological fluid, to determine the presence of LAV antigen in a biological fluid, or within a method for producing antibodies to LAV through the immunization of an animal with the peptide. Further, the pNEV-3 encoded peptides may be used as a vaccine against infection by the causative virus for acquired immune deficiency syndrome.

REFERENCES:
patent: 4520113 (1985-05-01), Gallo et al.
patent: 4525300 (1985-06-01), Yoshida et al.
patent: 4554101 (1985-11-01), Hopp
patent: 4572800 (1986-02-01), Shimizu et al.
patent: 4629783 (1986-12-01), Cosano
Schupbach et al., Science, 224, (1984), 503.
Sarngadharan et al., Science, 224, (1984), 506.
Schupbach et al., N.E. J. Med., 312, (1985), 265.
Laurence et al., N.E. J. Med., 311, (1984), 1269.
Levy et al., Science, 2251, (1984), 840.
Kaminsky et al., PNAS, 82, (1985), 5535.
Kalyanaraman et al., Science, 225, (1985), 321.
Vilmer et al., Lancet, 1, (1984), 753.
Kitchen et al., Nature, 312, (1984), 367.
Wain-Hobson et al., Cell, 40, (1985), 9.
Muesing et al., Nature, 313, (1985), 450.
Allan et al., Science, 228, (1985), 1091.
Sanchez-Pescador et al., Science, 227, (1985), 484.
Crowl et al., Cell, 41, (1985), 979.
Chang et al., Science, 228, (1985), 93.
Chang et al., Biotechnology, 3, (1985), 905.
Veronese et al., Science, 229, (1985), 1402.

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