Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1989-07-28
1992-12-29
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 5, 435 712, 4351721, 4351723, 4352523, 4353201, 435974, 536 27, 935 9, 935 12, 935 27, 935 72, 935 73, 930220, C12N 1549, C12P 1500, C12P 2100, C12P 2102
Patent
active
051750988
ABSTRACT:
Immunologically reactive gag proteins of LAV are expresesed in bacterial cells. The gag proteins are encoded by a recombinant plasmid containing procaryotic transcriptional and translational signals for expression, followed downstream by a DNA sequence comprising a portion of the gag region of LAV. Preferred signals for expression are selected from an inducible and/or suppressible operon, such as the trp operon. The gag proteins are isolated from the bacterial host and are utilized in diagonstic assays which detect the presence of LAV antigens or antibodies immunologically reactive with LAV. Further, the proteins produced by the method disclosed may be used as a vaccine against infection by the caustive virus for acquired immune deficiency syndrome.
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Cosand Wesley L.
McArdle Susan
Ward Pamela J.
Watanabe Susan M.
Genetic Systems Corporation
Railey II Johnny F.
Schwartz Richard A.
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