Expressing gp140 fragment of primary HIV-1 isolate

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence

Reexamination Certificate

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C530S300000, C514S002600, C424S185100, C424S186100, C424S188100

Reexamination Certificate

active

09914205

ABSTRACT:
A vector for eliciting an immune response to a host comprising a gene encoding the gp140 protein of the primary isolate of HIV-1, BX08, under the control of a promotor for expression of the protein in the host, specifically plasmids pCMV.gp140.BX08, pMP83, pMP84 and pMP88. Murine and human MHC class 1-restricted binding motifs contained in BX08 are identified.

REFERENCES:
patent: 5976541 (1999-11-01), Berzofsky et al.
patent: 5981706 (1999-11-01), Wallen et al.
patent: 6534482 (2003-03-01), Fikes et al.
patent: 2002/0168374 (2002-11-01), Kubo et al.
patent: WO 93/18055 (1993-08-01), None
patent: WO 97/34617 (1997-09-01), None
Verrier et al. (1997) PNAS, vol. 94 (17), 9326-9331.

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