Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-05-16
2006-05-16
Chan, Christina (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C424S192100, C424S193100, C424S185100, C530S391100
Reexamination Certificate
active
07045302
ABSTRACT:
The present invention provides for a modified TIE-2 ligand 2 which has been altered by addition, deletion or substitution of one or more amino acids, or by way of tagging, with for example, the Fc portion of human IgG-1, but which retains its ability to bind the TIE-2 receptor.
REFERENCES:
patent: 6265564 (2001-07-01), Davis et al.
patent: WO96/11269 (1996-04-01), None
patent: WO96/31598 (1996-10-01), None
Science, Maisonpierre, P.C., et al., (1997) “Angiopoietin-2, a Natural Antagonist for Tie2 that Disrupts in vivo Angiogenesis”, 277:55-60.
Davis Samuel
Yancopoulos George D.
Chan Christina
Gregg, Esq. Valeta
Haddad Maher
Regeneron Pharmaceuticals Inc.
Yang Ying-Zi
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