Export and modification of (poly)peptides in the lantibiotic...

Details Export and modification of (poly)peptides in the lantibiotic... Export and modification of (poly)peptides in the lantibiotic...

2005-03-01

2005-03-01

Carlson, Karen Cochrane (Department: 1653)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S325000, C530S323000

Reexamination Certificate

active

06861236

ABSTRACT:
The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intracellular posttranslational modification, such as dehydration of a serine or a threonine, and/or thioether bridge formation. The invention also includes a method for producing thioether-containing peptides and dehydroalanine/dehydrobutyrine-containing.peptides, wherein thioether rings may be formed extracellularly.

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