Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – The nonhuman animal is a model for human disease
Reexamination Certificate
2005-08-02
2005-08-02
Falk, Anne-Marie (Department: 1636)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
The nonhuman animal is a model for human disease
Reexamination Certificate
active
06924413
ABSTRACT:
This invention provides experimental animals suffering corneal epithelial damages, such as dry eye, and methods of using the same to assay a variety of compounds for evaluating the therapeutic effect on the disease, and medicine selected using the method, wherein the corneal epithelial damage is induced by the steps of: using a water-absorbing material having a physical state selected from powder, solution, gel, jelly and tablet, and contacting the absorbing materials with the ocular cornea to generate a difference in osmotic pressure between the inside and outside of ocular corneal epithelium cells.
REFERENCES:
patent: 5900407 (1999-05-01), Yerxa et al.
patent: 09-124505 (1997-05-01), None
patent: 09-136832 (1997-05-01), None
BSS, www.home.intekom.com/pharm/alcon, Balanced Salt Solution.
Gilbard et al., Morphologic effect of hyperosmolarity on rabbit corneal epithelium, 1984, OPTHALMOLOGY, vol. 91, pp. 1205-1212.
Fujihara et al., establishment of a rabbit short-term dry eye model, 1995, Journal Of Ocular Pharmacology, vol. 11, pp. 503-508.
Gans, The eye, 1970, Biology Of The Reptilia, vol. 2, pp. 1-97.
Indu Arora et al., Ophthalmology, vol. 101, No. 12, Dec. 1994, pp. 1935-1940.
Daniel Meller et al., Opthalmic Research vol. 28, No. 2, 1996, pp. 71-79.
Jeffrey W. Ruberti et al., Investigative Opthalmology & Visual Science, Aug. 2000, vol. 41, No. 9, pp. 2523-2530.
Uno T. et al., IVOS, vol. 42, No. 4, pp. S263, 2001.
Peter M. Andrews et al., Cornea, vol. 13, No. 3, pp. 253-258, 1994.
Burgalassi et al.; Ophthalmic Research; vol. 31; No. 3; 1999 pp. 229-235; XP001030110.
Tsubota et al.; British Journal of Ophthalmology; vol. 83; No. 4; Apr. 1999; pp. 390 395; XP002275298.
Karaki; Folia Ophthalmologica Japonica 1980 Japan; vol. 31; No. 8; 1980; pp. 1324-1328; XP009028453.
Katsuyama et al.; Journal of Ocular Pharmacology and Therapeutics; vol. 19; No. 3; Jun. 2003; pp. 281-289; XP009028430.
Biochemical and Pharmacological Laboratories, Inc.
Birch & Stewart Kolasch & Birch, LLP
Falk Anne-Marie
Sullivan Daniel M.
LandOfFree
Experimental animals for evaluation of therapeutic effects... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Experimental animals for evaluation of therapeutic effects..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Experimental animals for evaluation of therapeutic effects... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3443982