Expectorant comprising hydroxyalkylcysteine derivative

Details Expectorant comprising hydroxyalkylcysteine derivative Expectorant comprising hydroxyalkylcysteine derivative

1989-06-13

1991-09-10

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514855, A01N 3102, A01N 3308

Patent

active

050474286

ABSTRACT:
An expectorant comprising a hydroxyalkylcysteine derivative of the following formula (I) is disclosed. ##STR1## wherein n represents an integer of 1 to 4. The expectorant is stabile, has little side effects and toxicity, and exhibits an excellent expectorant effect.

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Yanaura et al., Japan J. Pharmacol., 1981 31(6), 957-65, Chem. Abs., vol. 96, 1982, Abstract 62815k.
Biochemical Pharmacology, (1961), vol. 6, pp. 205-216, "The Mode of Action of Alkylating Agents-II", J. J. Roberts et al.
Journal of Pharmaceutical Sciences, (1961), vol. 50, pp. 312-315, "Sulfide Derivative of Cysteine", Matthew Verderame.
Int. J. Peptide Protein Res., (1981), vol. 17, pp. 501-507, "Carbon 13 Nuclear Magnetic Resonance Studies on Formaldehyde Reactions . . . ", D. Tome et al.
International Journal of Clinical Pharmacology, Therapy and Toxicology, (1982), vol. 20, pp. 554-557, "Double-Blind Clinical Trial of Domiodol VS S-Carboxymethylcystein in Chronic Obstructive Lung Disease", L. Casali et al.

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