Expansion of human hematopoietic progenitor cells in a liquid me

Details Expansion of human hematopoietic progenitor cells in a liquid me Expansion of human hematopoietic progenitor cells in a liquid me

1995-06-06

1998-04-28

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435366, 435383, 435384, 435385, 435386, 435404, 435405, 435406, 424937, C12N 500, A01N 6300, A01N 6500

Patent

active

057443610

ABSTRACT:
The use of individual or combinations of cytokines, particularly IL-3, GM-CSF, and c-kit ligand are employed for long-term hematopoiesis in serum free culture in the absence of stromal cells. The cultures can be used for evaluating compounds and their effect on hematopoiesis, particularly as to lifetime and nature of differentiation. In addition, the expanded cells may be used for engraftment in a mammalian host or enhancement of particular cell lineages in a mammalian host. The subject systems may be used with any mammalian hemopoietic cells, but finds particular application with primates, more particularly humans.

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