Expanding the eukaryotic genetic code

Details Expanding the eukaryotic genetic code Expanding the eukaryotic genetic code

2004-04-16

2009-11-17

Wang, Andrew (Department: 1656)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S199000, C435S320100, C435S325000, C435S069100

Reexamination Certificate

active

07618775

ABSTRACT:
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

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