Expanded porphyrin compositions for tumor inhibition

Details Expanded porphyrin compositions for tumor inhibition Expanded porphyrin compositions for tumor inhibition

2006-02-21

2006-02-21

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

C540S145000, C534S015000, C514S185000, C514S410000, C424S009100, C424S009610

Reexamination Certificate

active

07001588

ABSTRACT:
Expanded porphyrin comprising substitutions for at least two NH groups by S, Se or Te are non-photoactive and are selective for binding G-quadruplexes characteristic of the c-MYC control region. Accordingly, these expanded porphyrins are useful to modulate the expression of genes controlled by the formation of c-MYC type G-quadruplexes, such as c-MYC itself.

REFERENCES:
Narayanan et al. Interaction of RH(I) with meso-Arylsapphyrinsa and -Rubyrins: First Structural Characterization of Bimetallic Hetero-rubyrin Complex. Feb. 21, 2001, Inorg. Chem. 2001, 40, pp. 1637-1645.
Narayanan et al. Novel Core-Modified Expanded Porphyrins with meso-Aryl Sustituents: Syhtesis, Spectral and Structural Characterization. Sep. 21, 1999, J. Am. Chem. Soc. 1999, 121, pp. 9053-9068.
Foye et al. Principles of Medicinal Chemistry. 1995. Williams & Wilkins. Fourth Edition. pp. 902-907.
Goldman et al. Cecil Textbook of Medicine. 2000. W.B. Saunders Company. Twenty-First Edition. p. 558.
Narayanan et al. Interaction of Rh(I) with meso-arylsapphyrins and -Rubyrins: First Structural Characterization of Bimetallic Hetero-rubyrin Complex. Inorg Chem. 2001, 40, pp. 1637-1645.
Narayanan et al. Novel Core-Modified Expanded Porphyrins with meso-Aryl Substituents: Synthesis, Spectral and Structural Chracterization. J. Am. Chem. Soc. 1999, 121. pp. 9053-9068.
Hilmey et al., J. Med. Chem. (2002) 45:449-461.
Stilts et al., J. Med. Chem. (2000) 43:2403-2410.

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