Expandable medical device for delivery of beneficial agent

Details Expandable medical device for delivery of beneficial agent Expandable medical device for delivery of beneficial agent

2005-11-14

2010-12-14

Willse, David H (Department: 3774)

Prosthesis (i.e., artificial body members), parts thereof, or ai

Arterial prosthesis

Drug delivery

C623S001440, C623S001460

Reexamination Certificate

active

07850727

ABSTRACT:
An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of the strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decreasing, sinusoidal, and other delivery profiles.

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