Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Aluminum – calcium or magnesium element – or compound containing
Patent
1987-12-21
1989-08-15
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Aluminum, calcium or magnesium element, or compound containing
424682, 424689, 424666, A61K 3308
Patent
active
048573248
ABSTRACT:
There are provided gastric cytoprotective exogenously acidified aluminum hydroxide antacid compositions which are formed by acidifying, for example, commercial liquid antacid suspensions containing aluminum hydroxide, antacid powders or solids containing aluminum hydroxide, or aluminum hydroxide gel, to the point where the aluminum hydroxide is solubilized. The solutuions may be formulated into liquid dosage forms or spray dried and formulated into solid dosage forms.
REFERENCES:
J. Wenger et al., J. Clin. Pharmacol., 12:13b, Apr. 1972, pp. 136-141.
L. J. Boyd, et al, Review of Gastroenterology 9:1, pp. 20-25, (Jan.-Feb., 1942).
I. Szelenyi, Acta Physiologica Hungarica, 64(3-4), pp. 259-268, (1984), Functional Cytoprotection by Certain Antacids.
I. Szelenyi et al., European Journal of Pharmacology, 88,403-406, (1983), Evidence for a Functional Cytoprotective Effect Produced by Antacids in the Rat Stomach.
Borella Luis E.
DiJoseph John F.
Mir Ghulam N.
Reuter Gerald L.
American Home Products Corporation (Del.)
Routh John W.
Waddell Frederick E.
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