Exoenzyme toxin of Aeromonas salmonicida , and uses therefor

Details Exoenzyme toxin of Aeromonas salmonicida , and uses therefor Exoenzyme toxin of Aeromonas salmonicida , and uses therefor

2009-07-08

2010-12-14

Graser, Jennifer E (Department: 1645)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S252300, C435S069100, C435S069300, C424S234100, C424S236100

Reexamination Certificate

active

07851197

ABSTRACT:
A protein toxin namedAeromonas salmonicidaexoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a novel Calcium (or other cation concentration) dependent promoter ofA. salmonicida. Also disclosed are diagnostic, preventive, and therapeutic techniques, including the preparation of bacterin vaccines based on AexT for inducing immunity againstA. salmonicidainfections.

REFERENCES:
patent: WO 92/21370 (1992-12-01), None
patent: WO 97/23503 (1997-07-01), None
Bowie, et al., Science, vol. 247, pp. 1306-1310, p. 1306.
Mikayama et al., Proc. Natl. Acad. Sci. USA., Nov. 2003, vol. 90, pp. 10056-10060.
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Braun, et al., GenEmbl.: Database. Accession No. AF288366, Submitted Jul. 19, 2000.
Database Swall 'Online: EBI; Nov. 1, 1996 “ExoT of P.aeruginosa,” Database Accession No. Q51445, XP-002216069.
Database EMBL 'Online! EBI; Aug. 2, 2001 “Aeromonas salmonicidaADP-ribosyltransferase gene (aexT), complete cds and unknown gene,” Database Accession No. AF288366, XP-002216070.
Database Swall 'Online: EBI; Nov. 1, 1996 “ExoS of P. aeruginosa” Database Accession No. Q51448, XP-002216071.

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