Exoenzyme toxin of Aeromonas salmonicida , and uses therefor

Details Exoenzyme toxin of Aeromonas salmonicida , and uses therefor Exoenzyme toxin of Aeromonas salmonicida , and uses therefor

2006-12-14

2009-08-25

Graser, Jennifer E (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S234100, C530S350000

Reexamination Certificate

active

07579011

ABSTRACT:
A novel protein toxin namedAeromonas salmonicidaexoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a novel Calcium (or other cation concentration) dependent promoter ofA. salmonicida.Also disclosed are diagnostic, preventative, and therapeutic techniques, including the preparation of traditional, recombinant, and improved bacterin vaccines based on AexT for inducing immunity againstA. salmonicidainfections.

REFERENCES:
patent: WO 92/21370 (1992-12-01), None
patent: WO 97/23503 (1997-07-01), None
Mikayama et al. (Nov. 1993. Proc.Natl.Acad.Sci. USA, vol. 90 : 10056-10060.
Rudinger et al. (Jun. 1976. Peptide Hormones. Biol.Council. pp. 5-7).
Database Accession No. XP-002216069, “ExoT ofP. aeruginosa” (Nov. 1, 1996).
Database Accession No. AF288366, XP-002216070 “Aeromonas salmonicidaADP-ribosyltransferase gene (aexT), complete cds and unknown gene” (Aug. 2, 2001).
Data Accession No. XP-002216071, “ExoS ofP. aeruginosa”(Nov. 1, 1996).

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