Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-03-20
2007-03-20
Lewis, Patrick (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S025310, C536S025330, C536S025340
Reexamination Certificate
active
10652064
ABSTRACT:
Precursors for use in the synthesis of polynucleotides and methods of using the precursors in synthesizing polynucleotides are disclosed. The precursors include a heterocyclic base having an exocyclic amine group and a substituted or unsubstituted triaryl methyl protecting group bound to the exocyclic amine group.
REFERENCES:
patent: 2002/0045221 (2002-04-01), Dellinger et al.
patent: 2002/0055880 (2002-05-01), Unold et al.
patent: 2003/0129589 (2003-07-01), Koster et al.
patent: 0241363 (1987-10-01), None
patent: 1428810 (2004-06-01), None
patent: WO92/10092 (1992-06-01), None
Nyilas A., et al., “Synthesis of [3′(O)-5′(C)]Oxyacetamido Llinked Nucleotides”, Tetrahedron, vol. 46, No. 6, 1990, pp. 2149-2164.
Sekine, et al., “Introduction of the 4, 4′, 4″-Tris (Benzoyloxy)trityl group into the Exo Amino groups of deoxyribonucleotides and its properties” Tetrahedron, vol. 41, No. 23, 1985, pp. 5445-5453.
Sekine, et al., “Synthesis of Short Oligoribonucleotides bearing a 3′ - or 5′-terminal phosphate by use of 4, 4″, 4″-tris (4, 5-dichlorophtalimido)trityl) as a new 5′-hydroxyl protecting group” J. Amer. Chem. Society, vol. 108, 1986, pp. 4581-4586.
Mishra, Rakesh K. et a., “Protecting groups as purification tool in large-scale synthesis of small oligodeoxyribonucleotides”, Indian Journal of Chemistry, 1988, 27B(9), 817-820.
Sekine et al., “Synthesis of Oligodeoxyribonucleotides Involving a Rapid Procedure for Removal of Base-Protecting Groups by Use of the 4,4′, 4″- Tris(benzoyloxy) trityl (TBTr) Group”, Bull. Chem. Soc. Japan, vol. 59, pp. 1781-1789, (1986).
Kamimura et al., “Synthesis of Dodecaribonuecleotide, GUAUCAAUAAUG, by Use of “Fully” Protected Ribonucleotide Building Blocks”, J. Am. Chem. Soc. 1984, vol. 106, 4552-4557.
Will et al., “The Synthesis of Polyamide Nucleic Acids using a Novel Monomethoxytrityl Protecting-Group Strategy”, Tetrahedron, vol. 51, No. 44, pp. 12069-12082, 1985.
Katzhendler et al., “The Effect of Spacer, Linkage and Solid Support on the Synthesis of Oligonucleotides”, Tetrahedron, vol . 45, No. 9, pp. 2777-2792, 1989.
Iwase et al, “A New Method for the Synthesis of Capped Oligoribonucleotides by Use of an Appropriately Protected 7-Methylguanosine Diphosphate Derivative as a Donor for the Triphosphate Derivative as a Donor for the Triphosphate Bond Formation”, Tetrahedron Letters, vol. 29, No. 24, pp. 2969-2972, 1988.
Caruthers Marvin H.
Dellinger Douglas J.
Sierzchala Agnieszka B.
Agilent Technologie,s Inc.
Beck Michael J.
Lewis Patrick
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