Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Reexamination Certificate
2006-09-15
2010-11-02
Bristol, Lynn (Department: 1643)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
C530S387300, C530S387900, C530S388100, C530S389100
Reexamination Certificate
active
07824676
ABSTRACT:
A mouse cDNA library from gene fragments encoding proteins localizing at cell-cell junctions was screened by a technique visualizing localization of a protein to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.
REFERENCES:
patent: 6210670 (2001-04-01), Berg
patent: 6783969 (2004-08-01), Tang et al.
patent: 2004/0029114 (2004-02-01), Mack et al.
patent: 2004/0241653 (2004-12-01), Feinstein et al.
patent: 2007/0105122 (2007-05-01), Ota et al.
patent: 2008/0181896 (2008-07-01), Khan et al.
patent: WO-99/66038 (1999-12-01), None
patent: WO 00/58473 (2000-10-01), None
Alberts et al. Molecular Biol. of Cells, 3rd Ed. pp. 500-501 and pp. 950-954 (1994).
Bost et al. (Immunol. Invest. (1988) 17:577-586.
Bendayan (J. Histochem. Cytochem. (1995) 43:881-886).
Smith et al. (Nature Biotechnology 15:1222-1223 (1997)).
Brenner (Trends in Genetics 15:132-133 (1999)).
Sequence search alignment for SEQ ID No:4 (pp. 1-4, Feb. 2, 2009).
Geneatlas datasheet for “Amotl2” gene (pp. 1-3, Feb. 2, 2009).
Hashimoto et al. (Eur. J. Morphol. 38(4):263-267 (2000) Abstract only).
Adachi et al., “Mus musculus adult make testis cDNA, RIKEN full-length enriched library, clone:4932416D09 product: B-MOTIN (Fragment) homolog [Homo sapiens], full insert sequence” Database accession No. ak016526, XP002237595 (Feb. 9, 2001).
Kessler et al., “Mus musculus angiomotin-like protein 2 variant 1 (Amot 12) mRNA, partial cds.” Database accession No. AF175967, XP002237596 (Sep. 26, 1999).
Kessler et al., Database Genbank Accession No. AF175968. National Library of Medicine, Bethesda, MD (Aug. 6, 1999).
Kohler et al., “Continuous cultures of fused cells secreting antibody of predefined specificity”,Nature, 256(5517): 495-7, 1975.
Misawa et al., “A method to identify cDNAs based on localization of green fluorescent protein fusion products”,Proc. Natl. Acad. Sci. USA, 97: 3062-66, 2000.
Nishimura et al., “JEAP, A Novel Compnent of Tight Junctions in Exocrine Cells”,The Journal of Biological Chemistry, 277(7): 5583-87, 2002.
Ohara et al., “Homo sapiensAmot12 mRNA for angiomotin like 2, partial cds, other name:KIAA0989.” Database accession No. AB023206, XP002237597 (Apr. 9, 1999).
Strausberg, “Mus musculus, Similar to angiomotin like 2, clone MGC:36419 Image:5323888,DE mRNA, complete cds.” Database accession No. BC027824, XP002237598 (May 3, 2002).
European Search Report issued Apr. 2003 in a related foreign application.
Sugihara-Mizuno et al., Genes Cells, vol. 12, 2007, pp. 473-486.
Bratt, A. et al., “Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains,”Gene(2002); 298:69-77.
Database EMBL-SVA Sep. 26, 1999, Kessler, R. et al., “Leman coiled-coil protein (LCCP) identified from a glioblastoma cell line expression library,” Database accession No. AAD56361.
Database EMBL-SVA, Apr. 9, 1999, Nagase, T. et al., “Prediction of the coding sequences of unidentified human genes. XIII. The complete sequence of 100 new cDNA clones from brain which code for large proteins in vitro,” Database accession No. AB023206.
Ernkvist, M. et al., “The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells,”Blood(2009); 113(1):244-253.
Kessler, R. et al., Identification of the Putative Brain Tumor Antigen BF7/GE2 as the (De)Toxifying Enzyme Microsomal Expoxide Hydrolase,Cancer Research(2000); 60:1403-1409.
Nagase, T. et al., “Prediction of the Coding Sequences of Unidentified Human Genes. XIII. The Complete Sequences of 100 New cDNA Clones from Brain Which Code for Large Proteins in vitro,”DNA Research(1999); 6:63-70.
Troyanovsky, B. et al., “Angiomotin: An Angiostatin Binding Protein That Regulates Endothelial Cell Migration and Tube Formation,”The Journal of Cell Biology(2001); 152(6):1247-1254.
Asano Mayumi
Imai Toshio
Inoue Yoko
Morimoto Koji
Nishimura Miyuki
Bristol Lynn
Eisai R&D Management Co., Ltd.
Fish & Richardson P.C.
LandOfFree
Exocrine gland tight junction-constituting protein jeap family does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Exocrine gland tight junction-constituting protein jeap family, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Exocrine gland tight junction-constituting protein jeap family will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4251477