Exocellular polysaccharide produced by Streptococcus thermophilu

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536123, 5361231, 536127, A61K 31715, C07H 108, C08B 3700

Patent

active

060544430

ABSTRACT:
The invention relates to a new isolated polysaccharide originating from Streptococcus thermophilus comprising the following repeat structure, and which may be use for the preparation of a food, cosmetic or pharmaceutical composition intended for inhibiting .beta.-galactoside specific lectins. ##STR1##

REFERENCES:
patent: 3985901 (1976-10-01), Gonzalez Barberan
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Elgavish et al., "Lectin-carbohydrate interactions: different folds, common recognition principles", TiBS, vol. 22: 462-467, Dec. 1997.
Lemoine et al. "Structural Characterization of the Exocellular Polysaccharides Produced by Streptococcus thermophilus SFi39 and SFi12", Applied and Environmental Microbiology, vol. 63(9): 3512-3518, Sep. 1997.
Stingele et al., "Identification and Characterization of the eps (Exopolysaccharide) Gene Cluster from Streptococcus thermophilus Sfi6", Journal of Bacteriology, vol. 178(6): 1680-1690, Mar. 1996.
Stingele et al. "Disruption of the gene encoding penicillin-binding protein 2b (pbp2b) causes altered cell morphology and cease in exopolysaccharide production in Streptococcus thermophilus Sfi6", Molecular Microbiology, vol. 22(2): 357-366, 1996.
J. Cerning et al. "Exocellular polysaccharide production by Streptococcus thermopilus", Biotechnology Letters, vol. 10, No. 4, 1988, pp. 255-260.
Barondes et al., "Galectins: A Family of Animal .beta.-Galactoside-Binding Lectins", Cell, vol. 76, 597-598, 1994.
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Wollenberg et al., "Human Keratinocytes Release the endogenous .beta.-Galactoside-binding Soluble Lectin Immunoglobulin E (IgE-Binding Protein) which binds to Langerhans Cells Where It Modulates Their Binding Capacity for IgE Glycoforms"; Journal of Experimental Medicine, vol. 178, 777-785, 1993.
Kolenbrander et al., "Coaggregation: specific adherence among human oral plaque bacteria"; The FASEB Journal, vol. 7, 406-412, 1993.
Dubois et al.; "Colorimetric Method for Determination of Sugars and Related Substances", Analytical Biochemical., 28, No. 3, 350-356, Mar. 1956.
Neeser et al.; "A Quantitative Determination by Capillary Gas-Liquid Chromatography of Neutral and amino Sugars (as O-Methyloxime Acetates), and a Study on Hydrolytic Conditions for Glycoproteins and Polysaccharides in Order to Increase Sugar Recoveries"; Analytical BioChemistry, vol. 142, 58-57 (1984).

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