(Exo,exo)-7-oxabicyclo[2.2.1]heptane-2,3-dimethanol; monoacyl es

Details (Exo,exo)-7-oxabicyclo[2.2.1]heptane-2,3-dimethanol; monoacyl es (Exo,exo)-7-oxabicyclo[2.2.1]heptane-2,3-dimethanol; monoacyl es

1991-07-30

1993-11-30

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30793

Patent

active

052667103

ABSTRACT:
Disclosed herein is a process for preparing a novel monoester of the formula ##STR1## in which the associated novel diester ##STR2## is hydrolyzed in the presence of one or more water-soluble enzymes or microorganisms capable of selectively hydrolyzing the --O--C(O)--R.sup.1 group, wherein the treatment is carried out in a biphasic solvent system comprising an aqueous phase having the enzymes or microorganisms and an organic phase immiscible in water having the diester. Also disclosed is a process for preparing [1S-[1.alpha., 2.alpha.(Z),3.alpha.,4.alpha.]]-7-[3[[[[(1-oxoheptyl)amino]acetyl]amino]me thyl-7-oxabicyclo-[2.2.1]hept-2-yl]-5-heptenoic acid using this enzymatic/microbial process.

REFERENCES:
patent: 4143054 (1979-03-01), Sprague
patent: 4663336 (1987-05-01), Nakane et al.
patent: 4732853 (1988-03-01), Whitesides et al.
patent: 4957867 (1990-09-01), Minai et al.
Andreu et al., J.C.S. Perkin Trans., 1(11), 3209-3210 (1990).
Guanti et al., Tetrahedron Letters, 27, 4639 (1986).
R. Bloch et al., Tetrahedron Letters, 26, 4087 (1985).
J. Bryan Jones et al., Can. J. Chem., vol. 62, 2578-2582 (1984).
K. P. Lok et al., J. Am. Chem. Soc. 107, 2521-2526 (1985).

Affiliated with

Also associated with

Rating

(Exo,exo)-7-oxabicyclo[2.2.1]heptane-2,3-dimethanol; monoacyl es does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (Exo,exo)-7-oxabicyclo[2.2.1]heptane-2,3-dimethanol; monoacyl es, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (Exo,exo)-7-oxabicyclo[2.2.1]heptane-2,3-dimethanol; monoacyl es will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2097959