Exendin 4 polypeptide fragment

Details Exendin 4 polypeptide fragment Exendin 4 polypeptide fragment

2006-08-01

2009-10-27

Kosar, Andrew D (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S324000, C514S003100

Reexamination Certificate

active

07608587

ABSTRACT:
The present invention relates to an Exendin 4 polypeptide fragment, which has hypoglycemic activity, and can be used for the treatment of type II diabetes mellitus. The polypeptide sequence described herein is HGEGTX1TSDLSKQX2EEEAVX3LFIEWLKNGX4PX5, where X1represents Phe or Tyr, X2represents Met, Ile or Leu, X3represents Lys, X4represents Gly or deletion, X5represents Arg or deletion. Additionally, the present invention relates to a method for the Exendin 4 polypeptide fragment preparation.

REFERENCES:
patent: 5424286 (1995-06-01), Eng
patent: 2007/0203058 (2007-08-01), Lau et al.
patent: 1 386 930 (2004-02-01), None
patent: WO 2004/035754 (2004-04-01), None
patent: WO 2004/036186 (2004-04-01), None

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