Exendin-3 and exendin-4 polypeptides, and pharmaceutical composi

Details Exendin-3 and exendin-4 polypeptides, and pharmaceutical composi Exendin-3 and exendin-4 polypeptides, and pharmaceutical composi

1993-05-24

1995-06-13

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514866, 435 691, 530324, A61K 3816, C07K 1446, C12N 1563

Patent

active

054242860

ABSTRACT:
This invention encompasses pharmaceutical compositions containing exendin-3 or exendin-4, fragments thereof, or any combination thereof, and methods for the treatment of diabetes mellitus and the prevention of hyperglycemia.

REFERENCES:
Schmidt et al. 1985. Diabetologia 28:704-707.
J. Eng & C. Eng, Exendin-3 and -4 are Insulin Secretagogues; Regulatory Peptides 40: 142 (1992).
Eng, J. et al., Purification and Structure of Exendin-3, a New Pancreatic Secretagogue Isolated from Heloderma horridum Venom; J. Biol. Chem. 265:20259 (1990).
Raufman, J. -P., Exendin-3 a Novel Peptide from Heloderma horridum Venom, Interacts with Vasoactive Intestinal Peptide Receptors and a Newly Described Receptor on Dispersed Acini from Guinea Pig Pancreas; J. Biol. Chem. 266:2897 (1991).
Eng, J. et al., Isolation and Characterization of Exendin-4, an Exendin-3 Analogue, from Heloderma suspectum Venom; J. Biol. Chem. 267:7402 (1992).
Raufmann, J. -P., et al., Truncated Glucagon-like-Peptide-1 Interacts with Exendin Receptors on Dispersed Acini from Guinea Pig Pancreas; J. Biol. Chem. 267:21432 (1992).
John Eng, Exendin Peptides; The Mt. Sinai J. of Med. 59: 147 (1992).
Gutniak, M. et al., Antidiabetogenic Effect of Glucagon-Like Peptide-1 (7-36) Amide in Normal Subjects and Patients with Diabetes Mellitus; The New England J. Med. 326:1316 (1992).

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