Exemestane compounds, compositions and related methods of use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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C552S640000

Reexamination Certificate

active

07846918

ABSTRACT:
6-Methyloxaalkyl exemestane compounds and related compositions, as can be used, chemotherapeutically, to inhibit growth and proliferation of cancer cells.

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patent: WO 2005/070951 (2005-08-01), None
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Numazawa, M; Ando, M; and Zennyoji, R; Studies on the Catalytic Function of Aromatase: Aromatization of 6-Alkoxy-Substituted Androgens; Journal of Steroid Biochemistry & Molecular Biology, 2002, 65-73, vol. 82.
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Gorlitzer, K; Bonnekessel, C; Jones, PG; and Kaufmann, G.; Unerwartete Bildung eines Estron-Derivates aus Androsta-1,4-dien-3,17-dion; Pharmazie, 2002, 808-810, vol. 57.
Mitsuteru Numazawa, Momoko Ando, Yoko Watari, Takako Tominaga, Yasuko Hayata, Akiko Yoshimura, Structure-activity relationship of 2-, 4-, or 6-substituted estrogens as aromatase inhibitors, The Journal of Steroid Biochemistry and Molecular Biology, 96, 2005 51-58, Elsevier Ltd.
Goerlitzer, Klaus, et al. Exemestane-synthesis and analysis, Deutsche Apotheker Zeitung; ISSN; 0011-9857, vol. 145, No. 37, Sep. 19, 2005.

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